caa a22 4500 463208226 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10863-007-9088-8 doi (NATIONALLICENCE)springer-10.1007/s10863-007-9088-8 Actuality of Warburg's views in our understanding of renal cancer metabolism [Elektronische Daten] [Catherine Godinot, Elodie de Laplanche, Eric Hervouet, Hélène Simonnet] More than 50years ago, Warburg proposed that the shift in glucose metabolism from oxidative phosphorylation (OXPHOS) to glycolysis occurring in spite of an adequate oxygen supply was at the root of cancer. This hypothesis often disregarded over the following years has recently stirred up much interest due to progress made in cancer genetics and proteomics. Studies related to renal cancers have been particularly informative to understand how abnormal use of glucose and decrease in OXPHOS are linked to cell proliferation in tumors. Indeed, in aggressive tumors such as clear cell renal carcinoma, the von Hippel-Lindau factor invalidation stabilizes the hypoxia-inducible factor (HIF) in the presence of oxygen. HIF stimulating glycolytic gene expression increases the glycolytic flux. Deficiencies in genes involved in oxidative phosphorylation that can explain the down-regulation of OXPHOS components also begin to be identified. These findings are important in the search for novel therapeutic approaches to cancer treatment. Springer Science+Business Media, LLC, 2007 Hypoxia-inducible factor nationallicence Glycolysis nationallicence Oxidative phosphorylation nationallicence Renal cancer nationallicence Godinot Catherine Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut de Laplanche Elodie Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut Hervouet Eric Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut Simonnet Hélène Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 235-241 0145-479X 39:3<235 2007 39 10863 https://doi.org/10.1007/s10863-007-9088-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9088-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Godinot Catherine Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut NATIONALLICENCE 700 1- de Laplanche Elodie Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut NATIONALLICENCE 700 1- Hervouet Eric Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut NATIONALLICENCE 700 1- Simonnet Hélène Center of Molecular and Cellular Genetics (CGMC), UMR 5534, CNRS, University Claude Bernard of Lyon 1, 43, Bvd du 11 novembre 1918, 69622, Villeurbanne, France aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 235-241 0145-479X 39:3<235 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer