caa a22 4500 463208234 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10863-007-9081-2 doi (NATIONALLICENCE)springer-10.1007/s10863-007-9081-2 Semenza Gregg Vascular Biology Program, Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, and McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA aut HIF-1 mediates the Warburg effect in clear cell renal carcinoma [Elektronische Daten] [Gregg Semenza] Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis in all metazoan species. O2-dependent hydroxylation of two proline residues in the HIF-1α subunit is necessary for the binding of the von Hippel-Lindau (VHL) protein, which is a component of a ubiquitin protein ligase that ubiquitinates HIF-1α, leading to its degradation by the proteasome. In the majority of cases of the clear cell type of renal carcinoma, both VHL genes are inactivated by mutation or epigenetic silencing, leading to dysregulated HIF-1 transcriptional activity. VHL loss-of-function leads, under aerobic conditions, to a HIF-1-dependent reprogramming of glucose and energy metabolism that includes increased glucose uptake, glycolysis, and lactate production accompanied by a reciprocal decrease in respiration. These findings delineate for the first time the molecular mechanisms underlying the Warburg effect in a human cancer. Springer Science+Business Media, LLC, 2007 Glucose transport nationallicence Glycolysis nationallicence Hypoxia nationallicence von Hippel-Lindau nationallicence Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 231-234 0145-479X 39:3<231 2007 39 10863 https://doi.org/10.1007/s10863-007-9081-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9081-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Semenza Gregg Vascular Biology Program, Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology, and McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 231-234 0145-479X 39:3<231 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer