caa a22 4500 463208242 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10863-007-9080-3 doi (NATIONALLICENCE)springer-10.1007/s10863-007-9080-3 Hypoxia, glucose metabolism and the Warburg's effect [Elektronische Daten] [Ramon Bartrons, Jaime Caro] As described by Warburg more than 50years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread. A key step in controlling glycolytic rate is the conversion of fructose-6-P to fructose-1,6-P2 by 6-phosphofructo-1-kinase (PFK-1). The activity of PFK-1 is allosterically controlled by fructose-2,6-P2, the product of the enzymatic activity of a dual kinase/phosphatase family of enzymes (PFKFB1-4) that are increased in a significant number of tumour types. In turn, these enzymes are induced by hypoxia through the activation of the HIF-1 complex (hypoxia-inducible complex-1), a transcriptional activator that controls the expression of most of hypoxia-regulated genes. HIF-1 complex is overexpressed in a variety of tumours and its expression appears to correlate with poor prognosis and responses to chemo or radiotherapy. Thus, targeting PFKFB enzymes, either directly or through inhibition of HIF-1, appears as a promising approach for the treatment of certain tumours. Springer Science+Business Media, LLC, 2007 Hypoxia nationallicence Glucose metabolism nationallicence Warburg's effect nationallicence Bartrons Ramon Unitat Bioquímica i Biologia Molecular, Departament de Ciències Fisiològiques, Campus de Ciències de la Salut, IDIBELL - Universitat de Barcelona, Barcelona, Spain aut Caro Jaime Cardeza Foundation, Thomas Jefferson University, 1015 Walnut St., 19107, Philadelphia, PA, USA aut Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 223-229 0145-479X 39:3<223 2007 39 10863 https://doi.org/10.1007/s10863-007-9080-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9080-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bartrons Ramon Unitat Bioquímica i Biologia Molecular, Departament de Ciències Fisiològiques, Campus de Ciències de la Salut, IDIBELL - Universitat de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Caro Jaime Cardeza Foundation, Thomas Jefferson University, 1015 Walnut St., 19107, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/3(2007-06-01), 223-229 0145-479X 39:3<223 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer