caa a22 4500 463208374 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10863-007-9121-y doi (NATIONALLICENCE)springer-10.1007/s10863-007-9121-y Timmons Lisa Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 5041 Haworth Hall, 66045-7534, Lawrence, KS, USA aut ABC transporters and RNAi in Caenorhabditis elegans [Elektronische Daten] [Lisa Timmons] RNAi is an evolutionarily conserved gene-silencing phenomenon that can be triggered by exogenous delivery of double stranded RNA to organisms. In Caenorhabditis elegans, the response to dsRNA is remarkably robust, and systemic RNAi responses are often observed. We have taken a genetic approach using this organism to better understand the mechanisms that facilitate RNAi. By analyzing strains of RNAi-defective mutants, we have uncovered an unexpected role for ABC transporters in RNAi and related silencing mechanisms. Ten of the sixty ABC transporter genes encoded in the C. elegans genome are required for robust RNAi. We will present data that highlights common features of these genes relative to their roles in RNAi, including genetic interactions with other components of the RNAi machinery. We will also describe unique roles for some transporter genes in endogenous RNAi-related processes. Springer Science+Business Media, LLC, 2007 RNAi nationallicence ABC transporter nationallicence Caenorhabditis elegans nationallicence dsRNA nationallicence Mutator nationallicence Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/5-6(2007-12-01), 459-463 0145-479X 39:5-6<459 2007 39 10863 https://doi.org/10.1007/s10863-007-9121-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9121-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Timmons Lisa Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 5041 Haworth Hall, 66045-7534, Lawrence, KS, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/5-6(2007-12-01), 459-463 0145-479X 39:5-6<459 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer