caa a22 4500 463208420 CHVBK 20180405153132.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10863-007-9119-5 doi (NATIONALLICENCE)springer-10.1007/s10863-007-9119-5 Role of CFTR's intrinsic adenylate kinase activity in gating of the Cl− channel [Elektronische Daten] [Christoph Randak, Michael Welsh] The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl−channel in the ATP-binding cassette (ABC) transporter protein family. CFTR features the modular design characteristic of ABC transporters, which includes two membrane-spanning domains forming the channel pore, and two ABC nucleotide-binding domains that interact with ATP and contain the enzymatic activity coupled to normal gating. Like other ABC transporters CFTR is an ATPase (ATP + H2O → ADP + Pi). Recent work has shown that CFTR also possesses intrinsic adenylate kinase activity (ATP + AMP ⇆ ADP + ADP). This finding raises important questions: How does AMP influence CFTR gating? Why does ADP inhibit CFTR current? Which enzymatic activity gates CFTR in vivo? Are there implications for other ABC transporters? This minireview attempts to shed light on these questions by summarizing recent advances in our understanding of the role of the CFTR adenylate kinase activity for channel gating. Springer Science+Business Media, LLC, 2007 CFTR nationallicence Adenylate kinase nationallicence ATPase nationallicence AMP nationallicence ADP nationallicence ABC transporter nationallicence Nucleotide binding nationallicence NBD nationallicence Cystic fibrosis nationallicence Chloride channel nationallicence Randak Christoph Department of Pediatrics, University of Iowa, 500 EMRB, 52242, Iowa, IA, USA aut Welsh Michael Department of Internal Medicine, Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa, 500 EMRB, 52242, Iowa, IA, USA aut Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/5-6(2007-12-01), 473-479 0145-479X 39:5-6<473 2007 39 10863 https://doi.org/10.1007/s10863-007-9119-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9119-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Randak Christoph Department of Pediatrics, University of Iowa, 500 EMRB, 52242, Iowa, IA, USA aut NATIONALLICENCE 700 1- Welsh Michael Department of Internal Medicine, Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa, 500 EMRB, 52242, Iowa, IA, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/5-6(2007-12-01), 473-479 0145-479X 39:5-6<473 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer