caa a22 4500 46320848X CHVBK 20180405153133.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10863-007-9105-y doi (NATIONALLICENCE)springer-10.1007/s10863-007-9105-y Structures of the FXYD regulatory proteins in lipid micelles and membranes [Elektronische Daten] [Carla Franzin, Xiao-Min Gong, Peter Teriete, Francesca Marassi] The FXYD membrane proteins constitute a family of conserved auxiliary subunits of the Na,K-ATPase, and have been the focus of recent attention due to their ability to finely regulate the activity of the enzyme complex in various physiological settings. In this review we describe the structures of the proteins, as well as their dynamics and their associations with the lipid bilayer membrane, which we have recently determined by NMR spectroscopy. Although the proteins are relatively small, their genes contain as many as six to nine small exons, and the coincidence of structured protein segments with their genetic elements suggests assembly from discrete structural modules through exon shuffling. The three-dimensional structures and backbone dynamics provide the foundation for understanding their intra-membrane association with the Na,K-ATPase α subunit, and the structure of FXYD1 suggests a mechanism whereby the phosphorylation of conserved Ser residues, by protein kinases A and C, could induce a conformational change in the cytoplasmic domain of the protein, to modulate its interaction with the α subunit. Springer Science+Business Media, LLC, 2007 FXYD nationallicence Na,K-ATPase nationallicence Structure nationallicence Membrane protein nationallicence Micelles nationallicence Membrane nationallicence NMR nationallicence Franzin Carla Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Gong Xiao-Min Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Teriete Peter Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Marassi Francesca Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/5-6(2007-12-01), 379-383 0145-479X 39:5-6<379 2007 39 10863 https://doi.org/10.1007/s10863-007-9105-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10863-007-9105-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Franzin Carla Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Gong Xiao-Min Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Teriete Peter Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Marassi Francesca Burnham Institute for Medical Research, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Journal of Bioenergetics and Biomembranes Springer US; http://www.springer-ny.com 39/5-6(2007-12-01), 379-383 0145-479X 39:5-6<379 2007 39 10863 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer