caa a22 4500 463209389 CHVBK 20180405153135.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00412-006-0081-5 doi (NATIONALLICENCE)springer-10.1007/s00412-006-0081-5 Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility [Elektronische Daten] [Marika Walter, Max Biessmann, Cecil Benitez, Tibor Török, James Mason, Harald Biessmann] Chromosome length in Drosophila is maintained by targeted transposition of three non-long terminal repeat retrotransposons, HeT-A, TART, and TAHRE, to the chromosome ends. The length and composition of these retrotransposon arrays can vary significantly between chromosome tips and between fly stocks, but the significance and consequences of these length differences are not understood. A dominant genetic factor, Tel, has been described, which causes a severalfold elongation of the retrotransposon arrays at all telomeres. We used this strain to assess possible affects of extended telomeres on the organism. While we found no effect on life span of the adults, we could demonstrate a correlation between long telomeres and reduced fertility and fecundity in individual females, which is also reflected in abnormal oocyte development. Springer-Verlag, 2006 Walter Marika Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut Biessmann Max Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut Benitez Cecil Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut Török Tibor Department of Genetics and Molecular Biology, University of Szeged, Szeged, Hungary aut Mason James Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, 27709, Research Triangle Park, NC, USA aut Biessmann Harald Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut Chromosoma Springer-Verlag 116/1(2007-02-01), 41-51 0009-5915 116:1<41 2007 116 412 https://doi.org/10.1007/s00412-006-0081-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00412-006-0081-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walter Marika Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Biessmann Max Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Benitez Cecil Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Török Tibor Department of Genetics and Molecular Biology, University of Szeged, Szeged, Hungary aut NATIONALLICENCE 700 1- Mason James Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, 27709, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Biessmann Harald Developmental Biology Center, University of California, 92697, Irvine, CA, USA aut NATIONALLICENCE 773 0- Chromosoma Springer-Verlag 116/1(2007-02-01), 41-51 0009-5915 116:1<41 2007 116 412 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer