caa a22 4500 463209508 CHVBK 20180405153136.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s00412-007-0114-8 doi (NATIONALLICENCE)springer-10.1007/s00412-007-0114-8 Another way to move chromosomes [Elektronische Daten] [Yuji Chikashige, Tokuko Haraguchi, Yasushi Hiraoka] A typical way of moving chromosomes is exemplified by mitotic segregation, in which the centromere is directly captured by spindle microtubules. In this study, we highlight another way of moving chromosomes remotely from outside the nucleus, which involves SUN and KASH domain nuclear envelope proteins. SUN and KASH domain protein families are known to connect the nucleus to cytoskeletal networks and play a role in migration and positioning of the nucleus. Recent studies in the fission yeast Schizossacharomyces pombe demonstrated an additional role for the SUN-KASH protein complex in chromosome movements. During meiotic prophase, telomeres are moved to rearrange chromosomes within the nucleus. The SUN-KASH protein complex located in the nuclear envelope is involved in this process. Telomeres are connected to the SUN protein on the nucleoplasmic side, and the dynein motor complex binds to the KASH protein on the cytoplasmic side. Telomeres are then moved along the nuclear envelope using cytoplasmic microtubules. These findings illustrate a general mechanism for transmitting a cytoskeletal driving force to chromosomes across the nuclear envelope. Springer-Verlag, 2007 Chikashige Yuji Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, 651-2492, Nishi-ku, Kobe, Japan aut Haraguchi Tokuko Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, 651-2492, Nishi-ku, Kobe, Japan aut Hiraoka Yasushi Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, 651-2492, Nishi-ku, Kobe, Japan aut Chromosoma Springer-Verlag 116/6(2007-12-01), 497-505 0009-5915 116:6<497 2007 116 412 https://doi.org/10.1007/s00412-007-0114-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00412-007-0114-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chikashige Yuji Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, 651-2492, Nishi-ku, Kobe, Japan aut NATIONALLICENCE 700 1- Haraguchi Tokuko Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, 651-2492, Nishi-ku, Kobe, Japan aut NATIONALLICENCE 700 1- Hiraoka Yasushi Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, 651-2492, Nishi-ku, Kobe, Japan aut NATIONALLICENCE 773 0- Chromosoma Springer-Verlag 116/6(2007-12-01), 497-505 0009-5915 116:6<497 2007 116 412 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer