caa a22 4500 463209540 CHVBK 20180405153136.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00412-007-0094-8 doi (NATIONALLICENCE)springer-10.1007/s00412-007-0094-8 The granulocyte nucleus and lamin B receptor: avoiding the ovoid [Elektronische Daten] [Katrin Hoffmann, Karl Sperling, Ada Olins, Donald Olins] The major human blood granulocyte, the neutrophil, is an essential component of the innate immunity system, emigrating from blood vessels and migrating through tight tissue spaces to the site of bacterial or fungal infection where they kill and phagocytose invading microbes. Since the late nineteenth century, it has been recognized that the human neutrophil nucleus is distinctly not ovoid as in other cell types, but possesses a lobulated (segmented) shape. This deformable nucleus enhances rapid migration. Recent studies have demonstrated that lamin B receptor (LBR) is necessary for the non-ovoid shape. LBR is an integral membrane protein of the nuclear envelope. A single dominant mutation in humans leads to neutrophils with hypolobulated nuclei (Pelger-Huet anomaly); homozygosity leads to ovoid granulocyte nuclei. Interestingly, LBR is also an enzyme involved in cholesterol metabolism. Homozygosity for null mutations is frequently lethal and associated with severe skeletal deformities. In addition to the necessity for LBR, formation of the mature granulocyte nucleus also depends upon lamin composition and microtubule integrity. These observations are part of a larger question on the relationships between nuclear shape and cellular function. Springer-Verlag, 2007 Hoffmann Katrin Department of Medical Genetics, Charite Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany aut Sperling Karl Department of Medical Genetics, Charite Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany aut Olins Ada Biology Department, Bowdoin College, 6500 College Station, 04011, Brunswick, ME, USA aut Olins Donald Biology Department, Bowdoin College, 6500 College Station, 04011, Brunswick, ME, USA aut Chromosoma Springer-Verlag 116/3(2007-06-01), 227-235 0009-5915 116:3<227 2007 116 412 https://doi.org/10.1007/s00412-007-0094-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00412-007-0094-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoffmann Katrin Department of Medical Genetics, Charite Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Sperling Karl Department of Medical Genetics, Charite Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Olins Ada Biology Department, Bowdoin College, 6500 College Station, 04011, Brunswick, ME, USA aut NATIONALLICENCE 700 1- Olins Donald Biology Department, Bowdoin College, 6500 College Station, 04011, Brunswick, ME, USA aut NATIONALLICENCE 773 0- Chromosoma Springer-Verlag 116/3(2007-06-01), 227-235 0009-5915 116:3<227 2007 116 412 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer