caa a22 4500 463209710 CHVBK 20180405153137.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00412-007-0113-9 doi (NATIONALLICENCE)springer-10.1007/s00412-007-0113-9 TFIIB and the regulation of transcription by RNA polymerase II [Elektronische Daten] [Wensheng Deng, Stefan Roberts] Accurate transcription of a gene by RNA polymerase II requires the assembly of a group of general transcription factors at the promoter. The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase II. TFIIB makes extensive contact with the core promoter via two independent DNA-recognition modules. In addition to interacting with other general transcription factors, TFIIB directly modulates the catalytic center of RNA polymerase II in the transcription complex. Moreover, TFIIB has been proposed as a target of transcriptional activator proteins that act to stimulate preinitiation complex assembly. In this review, we will discuss our current understanding of these activities of TFIIB. Springer-Verlag, 2007 Deng Wensheng Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, M13 9PT, Manchester, UK aut Roberts Stefan Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, M13 9PT, Manchester, UK aut Chromosoma Springer-Verlag 116/5(2007-10-01), 417-429 0009-5915 116:5<417 2007 116 412 https://doi.org/10.1007/s00412-007-0113-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00412-007-0113-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deng Wensheng Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, M13 9PT, Manchester, UK aut NATIONALLICENCE 700 1- Roberts Stefan Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, M13 9PT, Manchester, UK aut NATIONALLICENCE 773 0- Chromosoma Springer-Verlag 116/5(2007-10-01), 417-429 0009-5915 116:5<417 2007 116 412 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer