caa a22 4500 46321062X CHVBK 20180405153139.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00238-007-0147-5 doi (NATIONALLICENCE)springer-10.1007/s00238-007-0147-5 Protective effects of carvedilol on ischemia-reperfusion injury in rat epigastric island skin flaps [Elektronische Daten] [Murat Turker Ozyigit, Tayfun Turkaslan, Ozden Ertugrul, Bulent Ertugrul, Ugur Cevikbas, Zafer Ozsoy] Carvedilol, a selective alpha-1 and nonselective beta-adrenoceptor antagonist and potent antioxidant, has been shown to provide a significant decrease in neutrophil-mediated tissue injury. Epigastric skin flaps were elevated in rats, rendered ischemic for 10h, and subsequently reperfused for 12h. Forty rats were divided into four equal experimental groups: 1—nonischemic group, 2—ischemic saline control group, 3—ischemic control group without any vehicle treatment, and 4—drug-administered ischemic group. The effects of carvedilol on flap necrosis, neutrophil infiltration, and levels of malondialdehyde and nitric oxide in the flap tissue and serum were examined. The authors found that neutrophil numbers were significantly higher in the saline and nontreated groups. Additionally, serum and tissue levels of malondialdehyde were lower in the carvedilol-treated group, and serum nitric oxide was highest in the carvedilol-treated group. Carvedilol-treated animals had significantly lower areas of necrosis compared with controls. We conclude that administration of carvedilol before ischemia and reperfusion can significantly reduce the extent of flap necrosis and flap neutrophil counts because of ischemia-reperfusion injury. Springer-Verlag, 2007 Carvedilol nationallicence Ischemia-reperfusion injury nationallicence Skin flaps nationallicence Turker Ozyigit Murat Department of Plastic and Reconstructive Surgery, Vakif Gureba Training and Research Hospital, Sinanoba 1, Kisim A4 22 Blok D:1, BuyukCekmece, 34590, Istanbul, Turkey aut Turkaslan Tayfun Department of Plastic and Reconstructive Surgery, Vakif Gureba Training and Research Hospital, Sinanoba 1, Kisim A4 22 Blok D:1, BuyukCekmece, 34590, Istanbul, Turkey aut Ertugrul Ozden Department of Biochemistry, Aydin Government Hospital, Aydin, Turkey aut Ertugrul Bulent Department of Infectious Disease and Microbiology, Adnan Menderes University, Aydin, Turkey aut Cevikbas Ugur Istanbul Faculty of Medicine, Department Of Pathology, Istanbul University, Istanbul, Turkey aut Ozsoy Zafer Department of Plastic and Reconstructive Surgery, Vakif Gureba Training and Research Hospital, Sinanoba 1, Kisim A4 22 Blok D:1, BuyukCekmece, 34590, Istanbul, Turkey aut European Journal of Plastic Surgery Springer-Verlag 30/3(2007-11-01), 129-136 0930-343X 30:3<129 2007 30 238 https://doi.org/10.1007/s00238-007-0147-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00238-007-0147-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Turker Ozyigit Murat Department of Plastic and Reconstructive Surgery, Vakif Gureba Training and Research Hospital, Sinanoba 1, Kisim A4 22 Blok D:1, BuyukCekmece, 34590, Istanbul, Turkey aut NATIONALLICENCE 700 1- Turkaslan Tayfun Department of Plastic and Reconstructive Surgery, Vakif Gureba Training and Research Hospital, Sinanoba 1, Kisim A4 22 Blok D:1, BuyukCekmece, 34590, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ertugrul Ozden Department of Biochemistry, Aydin Government Hospital, Aydin, Turkey aut NATIONALLICENCE 700 1- Ertugrul Bulent Department of Infectious Disease and Microbiology, Adnan Menderes University, Aydin, Turkey aut NATIONALLICENCE 700 1- Cevikbas Ugur Istanbul Faculty of Medicine, Department Of Pathology, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ozsoy Zafer Department of Plastic and Reconstructive Surgery, Vakif Gureba Training and Research Hospital, Sinanoba 1, Kisim A4 22 Blok D:1, BuyukCekmece, 34590, Istanbul, Turkey aut NATIONALLICENCE 773 0- European Journal of Plastic Surgery Springer-Verlag 30/3(2007-11-01), 129-136 0930-343X 30:3<129 2007 30 238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer