caa a22 4500 463213661 CHVBK 20180405153149.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00339-007-4182-7 doi (NATIONALLICENCE)springer-10.1007/s00339-007-4182-7 Loading carbon nanotubes with viscous fluids and nanoparticles - a simpler approach [Elektronische Daten] [S.B. Nadarajan, P.D. Katsikis, E.S. Papazoglou] Carbon nanotubes have demonstrated exceptional properties enabling them to be considered for applications in drug delivery and other biologically important fields. The emphasis of the current drug delivery research with carbon nanotubes focuses on surface functionalization of the nanotubes and attachment of biomolecules, while leaving the inner void unmodified and mostly empty. Here, we report a simple, cost effective, and scalable method for filling and sealing carbon nanotubes with viscous solutions of biomaterials and nanoparticles (10 to 100nm). The loading of nanotubes was achieved by optimal centrifugation in the presence of the viscous solution containing nanoparticles. This novel method was found to be effective for loading nanoparticles from 10nm up to 40nm in diameter, while increased sedimentation of particles larger than 40nm resulted in reduced loading efficiency. Scanning electron microscopy and confocal laser scanning microscopy were used to analyze to confirm and image the loading of carbon nanotubes. This method could have immediate exciting applications in drug delivery especially for subcutaneous and slow release formulations. Springer-Verlag, 2007 Nadarajan S.B. School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, 19104, Philadelphia, PA, USA aut Katsikis P.D. Department of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, 19129, Philadelphia, PA, USA aut Papazoglou E.S. School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, 19104, Philadelphia, PA, USA aut Applied Physics A Springer-Verlag 89/2(2007-11-01), 437-442 0947-8396 89:2<437 2007 89 339 https://doi.org/10.1007/s00339-007-4182-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00339-007-4182-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nadarajan S.B. School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Katsikis P.D. Department of Microbiology and Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, 19129, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Papazoglou E.S. School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Applied Physics A Springer-Verlag 89/2(2007-11-01), 437-442 0947-8396 89:2<437 2007 89 339 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer