caa a22 4500 463218779 CHVBK 20180405153205.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1134/S106193480706007X doi (NATIONALLICENCE)springer-10.1134/S106193480706007X Validated spectrophotometric method for quantitative determination of simvastatin in pharmaceutical formulations and human serum [Elektronische Daten] [M. Arayne, N. Sultana, F. Hussain, S. Ali] A simple ultraviolet spectrophotometric method for the determination of simvastatin in methanol has been devised and compared with the existing pharmacopoeial RP-HPLC method for the estimation of the drug. Analytical parameters such as stability, selectivity, accuracy, and precision have been established for the method, using SIMS® tablets and human serum samples, and evaluated statistically to assess the application of the method. The method was validated under ICH and USP guidelines and was found to comprise the advantages for simplicity, stability, sensitivity, reproducibility, and accuracy for use as an alternative to existing nonspectrophotometric methods for the routine determination of the drug in pharmaceutical formulations and for pharmaceutical investigations involving simvastatin. Pleiades Publishing, Ltd., 2007 ultraviolet spectrophotometry nationallicence simvastatin nationallicence antihyperlipidemic nationallicence pharmaceutical analysis nationallicence Arayne M. Department of Chemistry, University of Karachi, 75270, Karachi, Pakistan aut Sultana N. Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, 75270, Karachi, Pakistan aut Hussain F. Quality Control Department, Noa Hemis Pharmaceuticals, 154/23, Korangi Industrial Area, 74900, Karachi, Pakistan aut Ali S. Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, 75270, Karachi, Pakistan aut Journal of Analytical Chemistry Nauka/Interperiodica 62/6(2007-06-01), 536-541 1061-9348 62:6<536 2007 62 10809 https://doi.org/10.1134/S106193480706007X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1134/S106193480706007X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arayne M. Department of Chemistry, University of Karachi, 75270, Karachi, Pakistan aut NATIONALLICENCE 700 1- Sultana N. Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, 75270, Karachi, Pakistan aut NATIONALLICENCE 700 1- Hussain F. Quality Control Department, Noa Hemis Pharmaceuticals, 154/23, Korangi Industrial Area, 74900, Karachi, Pakistan aut NATIONALLICENCE 700 1- Ali S. Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, 75270, Karachi, Pakistan aut NATIONALLICENCE 773 0- Journal of Analytical Chemistry Nauka/Interperiodica 62/6(2007-06-01), 536-541 1061-9348 62:6<536 2007 62 10809 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer