caa a22 4500 463220412 CHVBK 20180405153210.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1134/S1061934807050115 doi (NATIONALLICENCE)springer-10.1134/S1061934807050115 Determination of zopiclone in urine by gas chromatography-mass spectrometry [Elektronische Daten] [S. Kataev, N. Zelenina, Yu. Khomov, N. Koksharova, M. Daiekh] A procedure is described for the quantitative determination of zopiclone and the sum of its metabolites in urine using gas chromatography with the mass-spectrometric detection of their common hydrolysis product, 6-(5-chloro-2-pyridyl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-on. The procedure is very sensitive. The detection limit for ions with a mass of 45-450 au detected in the full scanning mode is 70 ng/mL. The data of gas chromatography-mass spectrometry are presented for different derivatives of the hydrolysis product of zopiclone; these data can be used for the qualitative identification of zopiclone. The stability of zopiclone and its metabolites upon time was studied by analyzing urine samples from patients receiving therapeutic doses of this substance stored for 1, 3, and 6 months. Pleiades Publishing, Ltd., 2007 Kataev S. Perm Regional Forensics Expertise Office, ul. Startseva 61, 614077, Perm, Russia aut Zelenina N. Perm Regional Forensics Expertise Office, ul. Startseva 61, 614077, Perm, Russia aut Khomov Yu Perm State Pharmaceutical Academy, ul. Lenina 48, 614000, Perm, Russia aut Koksharova N. Perm State Pharmaceutical Academy, ul. Lenina 48, 614000, Perm, Russia aut Daiekh M. Perm State Pharmaceutical Academy, ul. Lenina 48, 614000, Perm, Russia aut Journal of Analytical Chemistry Nauka/Interperiodica 62/5(2007-05-01), 458-462 1061-9348 62:5<458 2007 62 10809 https://doi.org/10.1134/S1061934807050115 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1134/S1061934807050115 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kataev S. Perm Regional Forensics Expertise Office, ul. Startseva 61, 614077, Perm, Russia aut NATIONALLICENCE 700 1- Zelenina N. Perm Regional Forensics Expertise Office, ul. Startseva 61, 614077, Perm, Russia aut NATIONALLICENCE 700 1- Khomov Yu Perm State Pharmaceutical Academy, ul. Lenina 48, 614000, Perm, Russia aut NATIONALLICENCE 700 1- Koksharova N. Perm State Pharmaceutical Academy, ul. Lenina 48, 614000, Perm, Russia aut NATIONALLICENCE 700 1- Daiekh M. Perm State Pharmaceutical Academy, ul. Lenina 48, 614000, Perm, Russia aut NATIONALLICENCE 773 0- Journal of Analytical Chemistry Nauka/Interperiodica 62/5(2007-05-01), 458-462 1061-9348 62:5<458 2007 62 10809 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer