caa a22 4500 463220501 CHVBK 20180405153210.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1134/S1061934807020128 doi (NATIONALLICENCE)springer-10.1134/S1061934807020128 Voltammetric behavior of some fluorinated quinolone antibacterial agents and their differential pulse voltammetric determination in drug formulations and urine samples using a β-cyclodextrin-modified carbon-paste electrode [Elektronische Daten] [T. Madhusudana Reddy, K. Balaji, S. Jayarama Reddy] A voltammetric determination of ofloxacin (OF), norfloxacin (NF), gatifloxacin (GF), and lomefloxacin (LF) at a β-cyclodextrin-modified carbon-paste electrode (CDMCPE) is described. A large increase in the peak currents was observed in cyclic voltammetry (CV) and differential pulse voltammetry (DPV) of OF, NF, GF, and LF at CDMCPE compared with a bare carbon-paste electrode (CPE). These increases in the peak currents were attributed to the complex formation of the quinone group of the drugs with β-cyclodextrin. CV studies indicate that the process is irreversible and adsorption-controlled. The experimental parameters which influence the peak current responses of OF, NF, GF, and LF were studied. The reduction peak currents of OF, NF, GF, and LF change linearly over the common concentration range from 3.2 × 10−8 to 2 × 10−5 M, with a common correlation coefficient and limit of detection of 0.9995 and 2.4 × 10−8 M, respectively, in pH 4.0 Britton-Robinson (BR) buffer at an accumulation time of 160 s. The interference of metal ions in the peak current response was also studied. The modified electrode exhibited good sensitivity and stability. The proposed method was applied to the determination of OF, NF, GF, and LF in both commercially available drugs and spiked human urine samples. Pleiades Publishing, Ltd., 2007 Madhusudana Reddy T. Electrochemical Research Laboratories, Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, India aut Balaji K. Electrochemical Research Laboratories, Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, India aut Jayarama Reddy S. Electrochemical Research Laboratories, Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, India aut Journal of Analytical Chemistry Nauka/Interperiodica 62/2(2007-02-01), 168-175 1061-9348 62:2<168 2007 62 10809 https://doi.org/10.1134/S1061934807020128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1134/S1061934807020128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madhusudana Reddy T. Electrochemical Research Laboratories, Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, India aut NATIONALLICENCE 700 1- Balaji K. Electrochemical Research Laboratories, Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, India aut NATIONALLICENCE 700 1- Jayarama Reddy S. Electrochemical Research Laboratories, Department of Chemistry, Sri Venkateswara University, 517502, Tirupati, India aut NATIONALLICENCE 773 0- Journal of Analytical Chemistry Nauka/Interperiodica 62/2(2007-02-01), 168-175 1061-9348 62:2<168 2007 62 10809 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer