caa a22 4500 46322230X CHVBK 20180405153216.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s10853-007-1706-7 doi (NATIONALLICENCE)springer-10.1007/s10853-007-1706-7 Preparation and characterization of polycaprolactone-chitosan composites for tissue engineering applications [Elektronische Daten] [Houde She, Xiufeng Xiao, Rongfang Liu] Highly porous scaffold plays an important role in bone tissue engineering, which becomes a promising alternative approach for bone repair since its emergence. The objective of this work was to blend poly (є-caprolactone) (PCL) with chitosan (CS) for the purpose of preparation of porous scaffold. A simple unique method was employed under room-temperature condition to blend the two components together without separation of two phases. The reaction leads to formation of sponge-like porous 5, 10, 15 and 20wt% CS composites. XRD, IR and SEM were used to determine components and morphology of the composites. DSC studies indicated that the miscibility of the two components. And pore volume fractures of composites were determined by a simple method in which a pycnometer was used. The results show that CS is successfully commingled into PCL matrix, and adding CS into PCL will not damage the crystalline structure of PCL. The composite shows no signs of phase separation and presents a unique porous structure under SEM observation. The porosity of composite increased with the increase of the content of CS in the composite. The highest porosity reached to 92% when CS content increased to 20wt%. The mechanism of formation of this unique porous structure is also discussed. Springer Science+Business Media, LLC, 2007 She Houde College of Chemistry and Materials Science, Fujian Normal University, 350007, Fujian, Fuzhou, China aut Xiao Xiufeng College of Chemistry and Materials Science, Fujian Normal University, 350007, Fujian, Fuzhou, China aut Liu Rongfang College of Chemistry and Materials Science, Fujian Normal University, 350007, Fujian, Fuzhou, China aut Journal of Materials Science Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 42/19(2007-10-01), 8113-8119 0022-2461 42:19<8113 2007 42 10853 https://doi.org/10.1007/s10853-007-1706-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1706-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- She Houde College of Chemistry and Materials Science, Fujian Normal University, 350007, Fujian, Fuzhou, China aut NATIONALLICENCE 700 1- Xiao Xiufeng College of Chemistry and Materials Science, Fujian Normal University, 350007, Fujian, Fuzhou, China aut NATIONALLICENCE 700 1- Liu Rongfang College of Chemistry and Materials Science, Fujian Normal University, 350007, Fujian, Fuzhou, China aut NATIONALLICENCE 773 0- Journal of Materials Science Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 42/19(2007-10-01), 8113-8119 0022-2461 42:19<8113 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer