caa a22 4500 463223713 CHVBK 20180405153220.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s10853-007-1851-z doi (NATIONALLICENCE)springer-10.1007/s10853-007-1851-z Synthesis and characterization of porous κ-carrageenan/calcium phosphate nanocomposite scaffolds [Elektronische Daten] [Ana Daniel-da-Silva, Augusto Lopes, Ana Gil, Rui Correia] The polysaccharide κ-carrageenan was used in the production of macroporous composites containing nanosized hydroxyapatite, with potential application in bone tissue engineering. Biodegradable composite scaffolds were prepared combining in situ co-precipitation of calcium phosphates with a freeze-drying technique. The effect of the Ca/P molar ratio and total ceramic content on the chemical composition, microstructure and mechanical performance of the scaffolds were investigated by thermal analysis, X-ray diffraction, FTIR, transmission electron microscopy, scanning electron microscopy, He porosimetry and compressive tests. A mixture of amorphous calcium phosphates and/or nanosized calcium-deficient hydroxyapatite was obtained in most of the composites. The formation of hydroxyapatite was induced by higher Ca/P ratios, probably due to competing reticulation of the biopolymer with calcium cations. The composite scaffolds presented interconnected pores (50-400μm) and porosity around 97% and calcium phosphates were uniformly dispersed in the κ-carrageenan matrix. Both microstructure and compressive mechanical properties of the scaffolds were affected by the ceramic content and, for a Ca/P molar ratio of 1.67, maximum compressive strength was achieved for a ceramic content of ca. 25wt%. Above this value the structural integrity of the composite was damaged and a dramatic decrease in mechanical strength was verified. Compressive mechanical properties of the composites were improved by increasing Ca/P atom ratio. Springer Science+Business Media, LLC, 2007 Daniel-da-Silva Ana Department of Chemistry, CICECO, University of Aveiro, 3810-193, Aveiro, Portugal aut Lopes Augusto Department of Ceramics and Glass Engineering, University of Aveiro, 3810-193, Aveiro, Portugal aut Gil Ana Department of Chemistry, CICECO, University of Aveiro, 3810-193, Aveiro, Portugal aut Correia Rui Department of Ceramics and Glass Engineering, University of Aveiro, 3810-193, Aveiro, Portugal aut Journal of Materials Science Springer US; http://www.springer-ny.com 42/20(2007-10-01), 8581-8591 0022-2461 42:20<8581 2007 42 10853 https://doi.org/10.1007/s10853-007-1851-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1851-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Daniel-da-Silva Ana Department of Chemistry, CICECO, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 700 1- Lopes Augusto Department of Ceramics and Glass Engineering, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 700 1- Gil Ana Department of Chemistry, CICECO, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 700 1- Correia Rui Department of Ceramics and Glass Engineering, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/20(2007-10-01), 8581-8591 0022-2461 42:20<8581 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer