caa a22 4500 463227360 CHVBK 20180405153231.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10853-006-1099-z doi (NATIONALLICENCE)springer-10.1007/s10853-006-1099-z Production of natural carotene-dispersed polymer microparticles by SEDS-PA co-precipitation [Elektronische Daten] [Wenzhi He, Quanling Suo, Hailong Hong, A Shan, Chunping Li, Yanchun Huang, Yunxia Li, Mingda Zhu] In this work, composite microparticles of poly (ethylene glycol) (PEG) loaded with natural carotene were successfully produced using solution enhanced dispersion by supercritical fluids through prefilming atomization (SEDS-PA) process. The characteristics of dispersion of carotene in the polymeric drug carrier were analyzed by color difference between carotene and PEG using optical micrographs. The morphologies and particle sizes (PSs) of the composite microparticles were studied by SEM micrographs. The precipitates were amorphous particles of PEG embedded with flake-like natural carotene crystals. The carotene degradation of the carotene/PEG composite microparticles was substantially lessened under the protection of PEG carrier in comparison with that of carotene microparticles. With the increase of the carotene content added in solution, the PSs of carotene crystals dispersed into the PEG carrier increase, the carotene loading yields in the composite microparticles (W c2) obviously increased, whereas PSs of these composite particles slightly decreased. Higher operating temperature resulted in formation of bigger coalesced composite particles and the substantial increase of W c2. With increase of operating pressure PSs decreased, whereas no clear dependence of W c2 was obtained on it. Springer Science+Business Media, LLC, 2007 He Wenzhi College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut Suo Quanling College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut Hong Hailong College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut Shan A. College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut Li Chunping College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut Huang Yanchun College of Chemistry and Environment Science, Inner Mongolia Normal University, 010022, Hohhot, P.R. China aut Li Yunxia College of Chemistry and Environment Science, Inner Mongolia Normal University, 010022, Hohhot, P.R. China aut Zhu Mingda College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut Journal of Materials Science Springer US; http://www.springer-ny.com 42/10(2007-05-01), 3495-3501 0022-2461 42:10<3495 2007 42 10853 https://doi.org/10.1007/s10853-006-1099-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-006-1099-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- He Wenzhi College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Suo Quanling College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Hong Hailong College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Shan A. College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Li Chunping College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Huang Yanchun College of Chemistry and Environment Science, Inner Mongolia Normal University, 010022, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Li Yunxia College of Chemistry and Environment Science, Inner Mongolia Normal University, 010022, Hohhot, P.R. China aut NATIONALLICENCE 700 1- Zhu Mingda College of Chemical Engineering, Inner Mongolia University of Technology, 010051, Hohhot, P.R. China aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/10(2007-05-01), 3495-3501 0022-2461 42:10<3495 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer