caa a22 4500 463232321 CHVBK 20180405153246.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10853-007-1918-x doi (NATIONALLICENCE)springer-10.1007/s10853-007-1918-x Nanomechanics and Raman spectroscopy of fibrillin 2 knock-out mouse bones [Elektronische Daten] [N. Kavukcuoglu, E. Arteaga-Solis, S. Lee-Arteaga, F. Ramirez, A. Mann] Absence of fibrillin 2 (Fbn2), a non-collagenous bone protein, causes a connective tissue disorder called congenital contractural arachnodactyly (CCA) and has been associated with decreased bone mineral density. Nanoindentation and Raman microspectroscopy have been used to compare the mechanical and chemical properties of cortical bone from femora of Fbn2−/− deficient mice and their wild-type controls (Fbn2+/+). It was found that Fbn2−/− bones have significantly lower hardness and elastic modulus compared to Fbn2+/+ bones, especially in the mid-cortical section. The Raman analysis showed little difference with genotype except for a decrease in type-B carbonate substitution in the endosteal region of Fbn2−/− bones. The results indicate that Fbn2 plays a direct role in determining the mechanical properties of bone. Springer Science+Business Media, LLC, 2007 Kavukcuoglu N. Materials Science & Engineering, Rutgers University, 08854, Piscataway, NJ, USA aut Arteaga-Solis E. Child Health Institute, UMDNJ-RWJMS, 08903, New Brunswick, NJ, USA aut Lee-Arteaga S. Child Health Institute, UMDNJ-RWJMS, 08903, New Brunswick, NJ, USA aut Ramirez F. Child Health Institute, UMDNJ-RWJMS, 08903, New Brunswick, NJ, USA aut Mann A. Materials Science & Engineering, Rutgers University, 08854, Piscataway, NJ, USA aut Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8788-8794 0022-2461 42:21<8788 2007 42 10853 https://doi.org/10.1007/s10853-007-1918-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1918-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kavukcuoglu N. Materials Science & Engineering, Rutgers University, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Arteaga-Solis E. Child Health Institute, UMDNJ-RWJMS, 08903, New Brunswick, NJ, USA aut NATIONALLICENCE 700 1- Lee-Arteaga S. Child Health Institute, UMDNJ-RWJMS, 08903, New Brunswick, NJ, USA aut NATIONALLICENCE 700 1- Ramirez F. Child Health Institute, UMDNJ-RWJMS, 08903, New Brunswick, NJ, USA aut NATIONALLICENCE 700 1- Mann A. Materials Science & Engineering, Rutgers University, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8788-8794 0022-2461 42:21<8788 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer