caa a22 4500 463232410 CHVBK 20180405153246.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10853-007-1952-8 doi (NATIONALLICENCE)springer-10.1007/s10853-007-1952-8 Buehler Markus Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Room 1-272, Cambridge, MA, USA aut Nano- and micromechanical properties of hierarchical biological materials and tissues [Elektronische Daten] [Markus Buehler] The mechanical properties of biological materials have been the focal point of extensive studies over the past decades, leading to formation of a new research field that intimately connects biology, chemistry and materials science. Significant advances have been made in many disciplines and research areas, ranging throughout a variety of material scales, from atomistic, molecular up to continuum scales. Experimental studies are now carried out with molecular precision, including investigations of how molecular defects such as protein mutations or protein knockout influence larger length- and time-scales. Simulation studies of biological materials now range from electronic structure calculations of DNA, molecular simulations of proteins and biomolecules like actin and tubulin to continuum theories of bone and collagenous tissues. The integration of predictive numerical studies with experimental methods represents a new frontier in materials research. The field is at a turning point when major breakthroughs in the understanding, synthesis, control and analysis of complex biological systems emerge. Here we provide a brief perspective of the state of this field and outline new research directions. Springer Science+Business Media, LLC, 2007 Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8765-8770 0022-2461 42:21<8765 2007 42 10853 https://doi.org/10.1007/s10853-007-1952-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1952-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Buehler Markus Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Room 1-272, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8765-8770 0022-2461 42:21<8765 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer