caa a22 4500 463232534 CHVBK 20180405153246.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10853-007-1720-9 doi (NATIONALLICENCE)springer-10.1007/s10853-007-1720-9 An lower bound on receptor density for stable cell adhesion due to thermal undulations [Elektronische Daten] [Yuan Lin, L. Freund] The adhesion of a living cell to an extracellular matrix surface is effected through the bonding of receptor molecules in the cell membrane to compatible ligand molecules on the surface. In a series of experiments on adhesion of cells to a substrate surface with a controlled density of ligand binding sites, Arnold etal. (ChemPhysChem 5:383, 2004) showed that tight cell adhesions could form only if the areal density of binding sites on the substrate was higher than some critical value. Furthermore, this critical value was consistent across the four cell types examined in the experiments. For ligand density below the critical level, on the other hand, virtually no adhesions formed. In this article, we examine the competition between thermal undulations of the cell membrane and its adhesion to the substrate. In particular, we show that thermal undulations destabilize membrane bonding to the substrate unless the bond spacing is below a certain level. By following this line of reasoning in the context of classical statistical mechanics, we obtain an estimate of the critical value of spacing which is in reasonable agreement with the observations. Springer Science+Business Media, LLC, 2007 Lin Yuan Division of Engineering, Brown University, 184 Hope Street, 02912, Providence, RI, USA aut Freund L. Division of Engineering, Brown University, 184 Hope Street, 02912, Providence, RI, USA aut Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8904-8910 0022-2461 42:21<8904 2007 42 10853 https://doi.org/10.1007/s10853-007-1720-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1720-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Yuan Division of Engineering, Brown University, 184 Hope Street, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Freund L. Division of Engineering, Brown University, 184 Hope Street, 02912, Providence, RI, USA aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8904-8910 0022-2461 42:21<8904 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer