caa a22 4500 463232577 CHVBK 20180405153246.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10853-007-1741-4 doi (NATIONALLICENCE)springer-10.1007/s10853-007-1741-4 Mechanical modeling of viral capsids [Elektronische Daten] [Melissa Gibbons, William Klug] As revealed by techniques of structural biology and single-molecule experimentation, the protein shells of viruses (capsids) are some of nature's best examples of highly symmetric multiscale self-assembled structures, with impressive mechanical properties of strength and elasticity. Mechanical models of viral capsids built "from the bottom up,” i.e., from all-atom models in the context of molecular dynamics and normal mode analysis, have chiefly focused on unforced vibrational capsid dynamics. Due to the size of viral capsids, which can contain several hundred thousand atoms, the computer power needed for these types of methods has only recently reached the level required for all-atom simulations of entire viral capsids. Coarse-grained normal mode analysis has provided a simplified means of studying the unforced vibrational dynamics of viral capsids. Recent focus on "top-down” mechanical models of viral capsids based on two- and three-dimensional continuum elasticity have provided a theoretical complement to single molecule experiments such as atomic force microscopy, and have advanced the fundamental understanding of the forced mechanics. This review serves to assess the current state of modeling techniques for the study of the mechanics of viral capsids, and to highlight some of the key insights gained from such modeling. In particular, a theme is established of a link between shape—or geometry—and the global mechanical properties of these hierarchical multiscale biological structures. Springer Science+Business Media, LLC, 2007 Gibbons Melissa Department of Mechanical and Aerospace Engineering, University of California, 90095, Los Angeles, CA, USA aut Klug William Department of Mechanical and Aerospace Engineering, University of California, 90095, Los Angeles, CA, USA aut Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8995-9004 0022-2461 42:21<8995 2007 42 10853 https://doi.org/10.1007/s10853-007-1741-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1741-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gibbons Melissa Department of Mechanical and Aerospace Engineering, University of California, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Klug William Department of Mechanical and Aerospace Engineering, University of California, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8995-9004 0022-2461 42:21<8995 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer