caa a22 4500 46323264X CHVBK 20180405153247.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10853-007-1831-3 doi (NATIONALLICENCE)springer-10.1007/s10853-007-1831-3 Time-dependant intercellular delamination of human stratum corneum [Elektronische Daten] [Kenneth Wu, James Li, K. Ananthapadmanabhan, Reinhold Dauskardt] Time-dependent intercellular delamination behavior of human stratum corneum (SC) is explored. We demonstrate that SC is susceptible to such time-dependent subcritical delamination at loads below the critical delamination energy. Hydration of the SC together with chemical treatments using selected surfactants were shown to affect both critical and subcritical delamination behavior. Increased tissue hydration resulted in accelerated delamination growth rates consistent with behavior anticipated from critical delamination testing. Chemical treatments including 10%wt/wt sodium dodecyl sulfate (SDS) and chloroform-methanol (2:1v:v) soaks that remove lipid were shown to suppress growth rates compared to untreated controls. Possible mechanisms for subcritical delamination involving extrinsic mechanisms of moisture-assisted reaction process at the intercellular delamination tip or intrinsic mechanisms involving kinetic relaxation processes in the SC are discussed. Springer Science+Business Media, LLC, 2007 Wu Kenneth Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut Li James Department of Materials Science and Engineering, Stanford University, 416 Escondido Mall, Bldg 550, Rm 550G, 94305-2205, Stanford, CA, USA aut Ananthapadmanabhan K. Unilever Research and Development, 06611, Trumbull, CT, USA aut Dauskardt Reinhold Department of Materials Science and Engineering, Stanford University, 416 Escondido Mall, Bldg 550, Rm 550G, 94305-2205, Stanford, CA, USA aut Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8986-8994 0022-2461 42:21<8986 2007 42 10853 https://doi.org/10.1007/s10853-007-1831-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-007-1831-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Kenneth Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Li James Department of Materials Science and Engineering, Stanford University, 416 Escondido Mall, Bldg 550, Rm 550G, 94305-2205, Stanford, CA, USA aut NATIONALLICENCE 700 1- Ananthapadmanabhan K. Unilever Research and Development, 06611, Trumbull, CT, USA aut NATIONALLICENCE 700 1- Dauskardt Reinhold Department of Materials Science and Engineering, Stanford University, 416 Escondido Mall, Bldg 550, Rm 550G, 94305-2205, Stanford, CA, USA aut NATIONALLICENCE 773 0- Journal of Materials Science Springer US; http://www.springer-ny.com 42/21(2007-11-01), 8986-8994 0022-2461 42:21<8986 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer