caa a22 4500 463234308 CHVBK 20180405153252.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s10853-006-0982-y doi (NATIONALLICENCE)springer-10.1007/s10853-006-0982-y Magnetically actuable polymer nanocomposites for bioengineering applications [Elektronische Daten] [Julia Mack, Brian Cox, Min Lee, James Dunn, Benjamin Wu] Methods are presented for creating biocompatible composites with magnetic functionality by incorporating magnetic nanoparticles in a biodegradable polymer matrix. A wide range of volume fractions for magnetic particle loading and therefore magnetization density are achievable. The nanoscale of the particles aids in achieving dispersion, so that variations in physical and chemical properties occur on scales much less than that of cells. Sufficient magnetization is achieved to enable actuation of the material, i.e., the generation of strains of biologically significant magnitudes using remotely applied magnetic fields. The magnitude of the actuation is demonstrated to enable fluid pumping and create local strains in cell aggregates that should be sufficient to stimulate cell growth and differentiation. The composite materials can be formed into random-pore scaffold materials with controlled porosity, pore shape, and pore connectivity. They can also be shaped by pressing, rolling, or drawing and joined by thermoplastic welding, so that ordered three-dimensional scaffold structures and various shell structures, such as tubes and toroids, can be fabricated. When the composite sheets are formed into tubes, the application of a moving magnetic field induces simulated peristalsis. When intestinal cells were seeded on the composite sheets, cells remained viable and grew rapidly invitro. Springer Science+Business Media, LLC, 2007 Mack Julia Teledyne Scientific Company, 1049 Camino Dos Rios, 91360, Thousand Oaks, CA, USA aut Cox Brian Teledyne Scientific Company, 1049 Camino Dos Rios, 91360, Thousand Oaks, CA, USA aut Lee Min Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 7523 Boelter Hall, P.O. Box 951600, 90095-1600, Los Angeles, CA, USA aut Dunn James Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 7523 Boelter Hall, P.O. Box 951600, 90095-1600, Los Angeles, CA, USA aut Wu Benjamin Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 7523 Boelter Hall, P.O. Box 951600, 90095-1600, Los Angeles, CA, USA aut Journal of Materials Science Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 42/15(2007-08-01), 6139-6147 0022-2461 42:15<6139 2007 42 10853 https://doi.org/10.1007/s10853-006-0982-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10853-006-0982-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mack Julia Teledyne Scientific Company, 1049 Camino Dos Rios, 91360, Thousand Oaks, CA, USA aut NATIONALLICENCE 700 1- Cox Brian Teledyne Scientific Company, 1049 Camino Dos Rios, 91360, Thousand Oaks, CA, USA aut NATIONALLICENCE 700 1- Lee Min Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 7523 Boelter Hall, P.O. Box 951600, 90095-1600, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Dunn James Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 7523 Boelter Hall, P.O. Box 951600, 90095-1600, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Wu Benjamin Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 7523 Boelter Hall, P.O. Box 951600, 90095-1600, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Materials Science Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 42/15(2007-08-01), 6139-6147 0022-2461 42:15<6139 2007 42 10853 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer