caa a22 4500 463234928 CHVBK 20180405153253.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10404-006-0093-8 doi (NATIONALLICENCE)springer-10.1007/s10404-006-0093-8 Control of serial microfluidic droplet size gradient by step-wise ramping of flow rates [Elektronische Daten] [John Collins, Abraham Lee] This paper describes a method to control and detect droplet size gradient by step-wise flow rate ramping of water-in-oil droplets in a microfluidic device. The droplets are generated in a cross channel device with two oil inlets and a water inlet. The droplet images are captured and analyzed in a time sequence in order to quantify the droplet generation frequency. It is demonstrated that by controlling the ramping of the oil flow rates it is possible to manipulate the ramping of droplet sizes. Increasing or decreasing of droplet sizes is achieved for a step-wise triangular ramping profile of the oil flow rate. The dynamic behavior of droplets due to the step-wise flow pulses is investigated. Uniform linear size ramping of water-in-oil droplets from 73 to 83μm in diameter is generated with an oil flow ramping range from 1 to 11μL/min in a minimum of five steps while water flow rate is held constant at 2μL/min. Springer-Verlag, 2006 Microfluidic droplets nationallicence Droplet sensing nationallicence High speed imaging nationallicence Droplet generation frequency nationallicence Microdroplet array nationallicence Collins John Department of Biomedical Engineering, University of California, Irvine, CA, USA aut Lee Abraham Department of Biomedical Engineering, University of California, Irvine, CA, USA aut Microfluidics and Nanofluidics Springer-Verlag 3/1(2007-02-01), 19-25 1613-4982 3:1<19 2007 3 10404 https://doi.org/10.1007/s10404-006-0093-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10404-006-0093-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Collins John Department of Biomedical Engineering, University of California, Irvine, CA, USA aut NATIONALLICENCE 700 1- Lee Abraham Department of Biomedical Engineering, University of California, Irvine, CA, USA aut NATIONALLICENCE 773 0- Microfluidics and Nanofluidics Springer-Verlag 3/1(2007-02-01), 19-25 1613-4982 3:1<19 2007 3 10404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer