caa a22 4500 463235096 CHVBK 20180405153254.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10404-007-0160-9 doi (NATIONALLICENCE)springer-10.1007/s10404-007-0160-9 A numerical design study of chaotic mixing of magnetic particles in a microfluidic bio-separator [Elektronische Daten] [M. Zolgharni, S. Azimi, M. Bahmanyar, W. Balachandran] A two-dimensional numerical investigation into the mixing of magnetic microparticles with bio-cells in a chaotic micromixer is carried out by using a multiphysics finite element analysis package. Fluid and magnetic problems are simulated in steady-state and time-dependent modes, respectively. Intensity of segregation is utilized as the main index to examine the efficiency of the mixer. Trajectories of the particles are used in order to detect chaos in their motion and quantify its extent. Moreover, probability of the collision between particles and target bio-cells is examined as a supplemental index to study the effects of driving parameters on the mixing process. Simulation results reveal that while in some ranges of operating conditions all indices are in good agreement, there are some ranges where they appear to predict contradicting results which is discussed in details. It is found that optimum operating conditions for the system is obtained when the Strouhal number is less than 0.6, which corresponds to the efficiency of about 85% in a mixing length of 500μm (The mixer design described here is patent pending). Springer-Verlag, 2007 Magnetic particles nationallicence Chaotic mixing nationallicence Microfluidics nationallicence Numerical nationallicence Zolgharni M. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut Azimi S. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut Bahmanyar M. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut Balachandran W. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut Microfluidics and Nanofluidics Springer-Verlag 3/6(2007-12-01), 677-687 1613-4982 3:6<677 2007 3 10404 https://doi.org/10.1007/s10404-007-0160-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10404-007-0160-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zolgharni M. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut NATIONALLICENCE 700 1- Azimi S. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut NATIONALLICENCE 700 1- Bahmanyar M. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut NATIONALLICENCE 700 1- Balachandran W. School of Engineering and Design, Brunel University, Uxbridge, UB8 3PH, Middlesex, UK aut NATIONALLICENCE 773 0- Microfluidics and Nanofluidics Springer-Verlag 3/6(2007-12-01), 677-687 1613-4982 3:6<677 2007 3 10404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer