caa a22 4500 463235169 CHVBK 20180405153254.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10404-006-0122-7 doi (NATIONALLICENCE)springer-10.1007/s10404-006-0122-7 Simulation and parametric study of a novel multi-spray emitter for ESI-MS applications [Elektronische Daten] [A. Sen, J. Darabi, D. Knapp] In this work, we propose a novel carbon nanofiber (CNF) emitter for electrospray ionization (ESI)-mass spectrometry (MS) applications. The proposed emitter comprises an array of CNFs around the orifice of a microscale capillary. The electrospray ionization process is simulated using a CFD code based on Taylor-Melcher leaky-dielectric formulations for solving the electrohydrodynamics and volume-of-fluid (VOF) method for tracking the interface. The code is validated for a conventional multiple electrospray emitter and then applied to simulate the CNF emitter model. The modeling results show that under steady state condition, individual cone-jets are established around each of the CNFs resulting in an array of electrosprays. The approach being taken to fabricate the CNF emitter is briefly discussed. Effects of geometrical parameters including aspect ratio of CNFs, total number of CNFs and distribution pattern of the CNFs on the electrospray performance are studied. The influence of operating parameters such as flow rate, potential difference and physical properties of the solvent on the electrospray behavior is thoroughly investigated. The spray current, ‘onset' potential and jet diameter are correlated with total number and distribution of CNFs and physical properties of the liquid. The correlation results are compared with the available results in the literature. Higher spray current and lower jet diameter indicate that the device can perform equivalent to nanospray emitters while using a micro-scale orifice. This allows higher sample throughput and eliminates potential clogging problem inherent in nano-capillaries. Springer-Verlag, 2006 Carbon nanofiber nationallicence Electrospray ionization-mass spectrometry nationallicence Taylor-Melcher leaky-dielectric formulations nationallicence Electrohydrodynamics nationallicence Volume of fluid nationallicence Sen A. MEMS and Microsystems Laboratory, Department of Mechanical Engineering, University of South Carolina, 300 Main Street, 29208, Columbia, SC, USA aut Darabi J. MEMS and Microsystems Laboratory, Department of Mechanical Engineering, University of South Carolina, 300 Main Street, 29208, Columbia, SC, USA aut Knapp D. Department of Pharmacology, Medical University of South Carolina, 173 Ashley Avenue, 29425, Charleston, SC, USA aut Microfluidics and Nanofluidics Springer-Verlag 3/3(2007-06-01), 283-298 1613-4982 3:3<283 2007 3 10404 https://doi.org/10.1007/s10404-006-0122-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10404-006-0122-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sen A. MEMS and Microsystems Laboratory, Department of Mechanical Engineering, University of South Carolina, 300 Main Street, 29208, Columbia, SC, USA aut NATIONALLICENCE 700 1- Darabi J. MEMS and Microsystems Laboratory, Department of Mechanical Engineering, University of South Carolina, 300 Main Street, 29208, Columbia, SC, USA aut NATIONALLICENCE 700 1- Knapp D. Department of Pharmacology, Medical University of South Carolina, 173 Ashley Avenue, 29425, Charleston, SC, USA aut NATIONALLICENCE 773 0- Microfluidics and Nanofluidics Springer-Verlag 3/3(2007-06-01), 283-298 1613-4982 3:3<283 2007 3 10404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer