caa a22 4500 463235207 CHVBK 20180405153254.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s10404-006-0139-y doi (NATIONALLICENCE)springer-10.1007/s10404-006-0139-y PIV measurements of flow within plugs in a microchannel [Elektronische Daten] [Colin King, Edmond Walsh, Ronan Grimes] The use of two-phase flow in lab-on-chip devices, where chemical and biological reagents are enclosed within plugs separated from each other by an immiscible fluid, offers significant advantages for the development of devices with high throughput of individual heterogeneous samples. Lab-on-chip devices designed to perform the polymerase chain reaction (PCR) are a prime example of such developments. The internal circulation within the plugs used to transport the reagents affects the efficiency of the chemical reaction within the plug, due to the degree of mixing induced on the reagents by the flow regime. It has been hypothesised in the literature that all plug flows produce internal circulation. This work demonstrates experimentally that this is false. The particle image velocimetry (PIV) technique offers a powerful non-intrusive tool to study such flow fields. This paper presents micro-PIV experiments carried out to study the internal circulation of aqueous plugs in two phase flow within 762μm internal diameter FEP Teflon tubing with FC-40 as the segmenting fluid. Experiments have been performed and the results are presented for plugs ranging in length from 1 to 13mm with a bulk mean flow velocity ranging from 0.3 to 50mm/s. The results demonstrate for the first time that circulation within the plugs is not always present and requires fluidic design considerations to ensure their generation. Springer-Verlag, 2006 Two-phase flow nationallicence Plug flow nationallicence Internal circulation nationallicence μPIV nationallicence King Colin Stokes Research Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Co. Limerick, Ireland aut Walsh Edmond Stokes Research Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Co. Limerick, Ireland aut Grimes Ronan Stokes Research Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Co. Limerick, Ireland aut Microfluidics and Nanofluidics Springer-Verlag 3/4(2007-08-01), 463-472 1613-4982 3:4<463 2007 3 10404 https://doi.org/10.1007/s10404-006-0139-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10404-006-0139-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- King Colin Stokes Research Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Co. Limerick, Ireland aut NATIONALLICENCE 700 1- Walsh Edmond Stokes Research Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Co. Limerick, Ireland aut NATIONALLICENCE 700 1- Grimes Ronan Stokes Research Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Castletroy, Co. Limerick, Ireland aut NATIONALLICENCE 773 0- Microfluidics and Nanofluidics Springer-Verlag 3/4(2007-08-01), 463-472 1613-4982 3:4<463 2007 3 10404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer