caa a22 4500 463235282 CHVBK 20180405153254.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s10404-006-0137-0 doi (NATIONALLICENCE)springer-10.1007/s10404-006-0137-0 Study on a piezoelectric micropump for the controlled drug delivery system [Elektronische Daten] [Qifeng Cui, Chengliang Liu, Xuan Zha] We present the design of a new controlled drug delivery system potential for in vitro injection of diabetics. The system incorporates some integrated circuit units and microelectromechanical system devices, such as micropump, microneedle array and microsensor. Its goal is to achieve safer and more effective drug delivery. Moreover, a valveless micropump excited by the piezoelectric actuator is designed for the drug delivery system, and a simple fabrication process is proposed. A dynamic model is developed for the valveless micropump based upon the mass conservation. To characterize the micropump, a complete electro-solid-fluid coupling model, including the diffuser/nozzle element and the piezoelectric actuator, is built using the ANSYS software. The simulation results show that the performance of micropump is in direct proportion to the stroke volume of the pump membrane and there is an optimal thickness of the piezoelectric membrane under the 500V/mm electric field. Based on this simulation model, the effects of several important parameters such as excitation voltage, excitation frequency, pump membrane dimension, piezoelectric membrane dimension and mechanical properties on the characteristics of valveless micropump have been investigated. Springer-Verlag, 2006 Drug delivery system nationallicence Valveless micropump nationallicence Simulation nationallicence Piezoelectric actuator nationallicence Optimization nationallicence Cui Qifeng School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China aut Liu Chengliang School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China aut Zha Xuan School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China aut Microfluidics and Nanofluidics Springer-Verlag 3/4(2007-08-01), 377-390 1613-4982 3:4<377 2007 3 10404 https://doi.org/10.1007/s10404-006-0137-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10404-006-0137-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cui Qifeng School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China aut NATIONALLICENCE 700 1- Liu Chengliang School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China aut NATIONALLICENCE 700 1- Zha Xuan School of Mechanical Engineering, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China aut NATIONALLICENCE 773 0- Microfluidics and Nanofluidics Springer-Verlag 3/4(2007-08-01), 377-390 1613-4982 3:4<377 2007 3 10404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer