caa a22 4500 46323538X CHVBK 20180405153255.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s10404-006-0145-0 doi (NATIONALLICENCE)springer-10.1007/s10404-006-0145-0 Numerical investigation of AC electrokinetic virus trapping inside high ionic strength media [Elektronische Daten] [Jeffery Wood, Bingbing Zhang, Matthew Tomkins, Aristides Docoslis] A numerical investigation of the mechanism by which viral particles suspended in physiologically relevant (i.e., high ionic strength) media can be electrokinetically sampled on a surface is presented. Specifically, sampling of virus from a droplet is taking place by means of a high frequency non-uniform electric field, generated by energized planar quadrupolar microelectrodes deposited on an oxidized silicon chip. The numerical simulations are based on experimental conditions applied in our previous work with vesicular stomatitis virus. A 3D computer model is used to yield the spatial profiles of electric field intensity, temperature, and fluid velocity inside the droplet, as well as the force balance on the virus. The results suggest that rapid virus sampling can be achieved by the synergistic action of dielectrophoresis and electrothermal fluid flow. Specifically, electrothermal fluid flow can be used to transport the virus from the bulk of a sample to the surface, where dielectrophoretic forces, which become significant only at very small length scales away from the surface, can cause its stable capture. Springer-Verlag, 2007 AC electrokinetics nationallicence Dielectrophoresis nationallicence Virus sampling nationallicence Surface-based biosensors nationallicence Microfluidics nationallicence Wood Jeffery Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut Zhang Bingbing Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut Tomkins Matthew Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut Docoslis Aristides Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut Microfluidics and Nanofluidics Springer-Verlag 3/5(2007-10-01), 547-560 1613-4982 3:5<547 2007 3 10404 https://doi.org/10.1007/s10404-006-0145-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10404-006-0145-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wood Jeffery Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 700 1- Zhang Bingbing Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 700 1- Tomkins Matthew Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 700 1- Docoslis Aristides Department of Chemical Engineering, Queen's University at Kingston, Dupuis Hall, Division Street, K7L 3N6, Kingston, ON, Canada aut NATIONALLICENCE 773 0- Microfluidics and Nanofluidics Springer-Verlag 3/5(2007-10-01), 547-560 1613-4982 3:5<547 2007 3 10404 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer