caa a22 4500 463237005 CHVBK 20180405153301.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s11259-007-3522-6 doi (NATIONALLICENCE)springer-10.1007/s11259-007-3522-6 Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition [Elektronische Daten] [T. Ndong, Y. Kane, E. Diouf, M. Alvinerie] The plasma disposition kinetics of ivermectin following a single subcutaneous administration of 0.2 mg/kg was investigated in male and female Senegalese Peulh sheep. Ten clinically healthy animals (5 males and 5 females) weighing 38-45 kg were used in this trial. Blood samples were collected by jugular puncture at different times between 0.5 h and 30 days post treatment. After plasma extraction and derivatization, samples were analysed by HPLC with fluorescence detection. Computerized kinetic analysis was carried out and mean parameters were statistically compared with the Mann-Whitney U-test. The area under the concentration-time curve (AUC) was significantly higher (p < 0.0027) in females than in males. Although the differences in maximum concentration (C max), mean residence time (MRT) and half-life of elimination (t 1/2el) between males and females did not achieve statistical significance, values tended to be higher in females. Sex differences may be parallel with the level of storage in fat. Further investigations are required to improve the use of ivermectin in Senegalese sheep and findings may be used to predict optimal anthelmintic strategies for management of African species depending on the parasites present in a production system. Springer Science + Business Media, Inc., 2007 Senegalese Peulh sheep nationallicence ivermectin nationallicence endectocides nationallicence pharmacokinetics nationallicence sex influence nationallicence efficacy nationallicence AUC : area under the plasma concentration-time curve nationallicence AUMC : area under the moment curve nationallicence C max : observed peak plasma concentration nationallicence HPLC : high-performance liquid chromatography nationallicence k a : constant rate of absorption nationallicence k 10 : constant of elimination nationallicence MRT : mean residence time nationallicence SPE : solid-phase extraction nationallicence t max : time to reach C max nationallicence ( t 1/2 k a) : half-life of absorption nationallicence t 1/2el : half-life of elimination nationallicence Ndong T. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal aut Kane Y. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal aut Diouf E. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal aut Alvinerie M. Laboratoire de Pharmacologie-Toxicologie, INRA UR 66, Toulouse, France aut Veterinary Research Communications Kluwer Academic Publishers 31/6(2007-08-01), 739-747 0165-7380 31:6<739 2007 31 11259 https://doi.org/10.1007/s11259-007-3522-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11259-007-3522-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ndong T. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal aut NATIONALLICENCE 700 1- Kane Y. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal aut NATIONALLICENCE 700 1- Diouf E. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal aut NATIONALLICENCE 700 1- Alvinerie M. Laboratoire de Pharmacologie-Toxicologie, INRA UR 66, Toulouse, France aut NATIONALLICENCE 773 0- Veterinary Research Communications Kluwer Academic Publishers 31/6(2007-08-01), 739-747 0165-7380 31:6<739 2007 31 11259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer