caa a22 4500 463237048 CHVBK 20180405153301.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s11259-007-0054-z doi (NATIONALLICENCE)springer-10.1007/s11259-007-0054-z Duration of Anthelmintic Effect of Three Formulations of Ivermectin (Oral, Injectable and Pour-on) Against Multiple Anthelmintic-Resistant Haemonchus contortus in Sheep [Elektronische Daten] [R. Garg, R. Kumar, C. Yadav, P. Banerjee] We report the results of investigations that were conducted in a sheep flock in Uttaranchal, India where repeated failure of anthelmintic medication was noted. The study revealed that Haemonchus contortus in sheep had developed resistance to benzimidazoles (fenbendazole, mebendazole and albendazole), imidazothiazole (levamisole) and salicylanide (rafoxanide), while it was fully susceptible to avermectins (ivermectin). Further, the suppression of nematode egg output in faeces of sheep naturally infected with multiple anthelmintic-resistant H. contortus following treatment with ivermectin tablet (0.4 mg/kg body weight (bw), orally), ivermectin injection (1% w/v, 0.2 mg/kg bw, subcutaneously) and ivermectin pour-on (0.5 w/v, 0.5 mg/kg bw) was also studied over a period of 10 weeks post treatment. It was noted that ivermectin tablet after initial clearance of infection (faecal egg count reduction 100%), could not prevent establishment of new patent natural infection for even a single day, while ivermectin pour-on and injection prevented the establishment of new infection for 7 and 14 days post treatment, respectively. Maximum protection period (duration for which mean faecal egg count of sheep reaches 500 eggs per gram of faeces or more) of 68 days was recorded in sheep treated with injectable ivermectin, followed by pour-on (60 days) and oral (53 days) preparations. Springer Science + Business Media, Inc., 2007 Haemonchus contortus nationallicence multiple anthelmintic resistance nationallicence ivermectin nationallicence persistent effect nationallicence sheep nationallicence bw : body weight nationallicence DPT : days post treatment nationallicence e.p.g. : eggs per gram of faeces nationallicence FEC : faecal egg count nationallicence FECRT : faecal egg count reduction test nationallicence GI : gastrointestinal nationallicence MDR : multiple drug-resistant nationallicence Garg R. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut Kumar R. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut Yadav C. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut Banerjee P. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut Veterinary Research Communications Kluwer Academic Publishers 31/6(2007-08-01), 749-755 0165-7380 31:6<749 2007 31 11259 https://doi.org/10.1007/s11259-007-0054-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11259-007-0054-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garg R. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut NATIONALLICENCE 700 1- Kumar R. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut NATIONALLICENCE 700 1- Yadav C. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut NATIONALLICENCE 700 1- Banerjee P. Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, G.B. P.U.A.& T., 263 145, Pantnagar, Uttaranchal, India aut NATIONALLICENCE 773 0- Veterinary Research Communications Kluwer Academic Publishers 31/6(2007-08-01), 749-755 0165-7380 31:6<749 2007 31 11259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer