caa a22 4500 463237277 CHVBK 20180405153302.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s11259-006-3427-9 doi (NATIONALLICENCE)springer-10.1007/s11259-006-3427-9 Multivariate Survival Analysis of Histological Parameters and Clinical Presentation in Canine Cutaneous Mast Cell Tumours [Elektronische Daten] [R. Preziosi, G. Sarli, M. Paltrinieri] The Patnaik histological grade is a good method for the prediction of long-term mast cell tumour behaviour but it is influenced by subjective inter-observer variations and intratumoral heterogeneity. The present study evaluated each of the histopathological parameters used to formulate Patnaik's grade in terms of prognosis and tested whether they have a different prognostic sensitivity, thereby disclosing which could be considered more useful in the prediction of tumour recurrence and patient survival. Clinical presentation (single or multiple tumours) was also considered as possible prognostic factor. The results demonstrated that individual histological criteria together with multiple presentation may be of value in predicting the outcome of mast cell tumours. Among these, invasiveness (β1.85; standard error 1.15) and the number of mitotic figures (β3.01; standard error 1.18) showed high prognostic significance (Cox proportional hazard regression for censored data ; chi-squared = 15.52, degree of freedom = 6, p = 0.016) and could serve as reliable prognostic indicators avoiding more subjective parameters such as cellular differentiation, nuclear morphology and tumoural pattern. Springer Science + Business Media, Inc., 2007 dog nationallicence mast cell tumour nationallicence histological grade nationallicence invasiveness nationallicence skin nationallicence hpf : high-power field nationallicence MCT : mast cell tumour nationallicence PFI : progress in-free interval nationallicence ST : survival time nationallicence Preziosi R. Dipartimento di Sanitá Pubblica Veterinaria e Patologia Animale, Settore Patologia Generale ed Anatomia Patologica, Bologna aut Sarli G. Dipartimento di Sanitá Pubblica Veterinaria e Patologia Animale, Settore Patologia Generale ed Anatomia Patologica, Bologna aut Paltrinieri M. via della Marasca 6, 44100, Ferrara, Italy aut Veterinary Research Communications Kluwer Academic Publishers 31/3(2007-04-01), 287-296 0165-7380 31:3<287 2007 31 11259 https://doi.org/10.1007/s11259-006-3427-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11259-006-3427-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Preziosi R. Dipartimento di Sanitá Pubblica Veterinaria e Patologia Animale, Settore Patologia Generale ed Anatomia Patologica, Bologna aut NATIONALLICENCE 700 1- Sarli G. Dipartimento di Sanitá Pubblica Veterinaria e Patologia Animale, Settore Patologia Generale ed Anatomia Patologica, Bologna aut NATIONALLICENCE 700 1- Paltrinieri M. via della Marasca 6, 44100, Ferrara, Italy aut NATIONALLICENCE 773 0- Veterinary Research Communications Kluwer Academic Publishers 31/3(2007-04-01), 287-296 0165-7380 31:3<287 2007 31 11259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer