caa a22 4500 463238486 CHVBK 20180405153305.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s11259-007-3343-7 doi (NATIONALLICENCE)springer-10.1007/s11259-007-3343-7 Plasma Concentrations, Pharmacokinetics and Urinary Excretion of Gatifloxacin after Single Intravenous Injection in Buffalo Calves [Elektronische Daten] [M. Raipuria, V. Dumka, H. Sandhu] The pharmacokinetics and urinary excretion of gatifloxacin were investigated after a single intravenous injection of 4 mg/kg body weight in buffalo calves. The therapeutic plasma drug concentration was maintained for up to 12 h. Gatifloxacin rapidly distributed from blood to tissue compartments, which was evident from the high values of the distribution rate constant, α1 (11.1 ± 1.06 h−1) and the rate constant of transfer of drug from central to peripheral compartment, k 12 (6.29 ± 0.46 h−1). The area under the plasma drug concentration-time curve and apparent volume of distribution were 17.1 ± 0.63 (μg.h)/ml and 3.56 ± 0.95 L/kg, respectively. The elimination half-life (t 1/2 β), total body clearance (ClB) and the ratio of drug present in tissues and plasma (T/P) were 10.4 ± 2.47 h, 235.1 ± 8.47 ml/(kg.h) and 10.1 ± 2.25, respectively. About 19.7% of the administered drug was excreted in urine within 24 h. A satisfactory intravenous dosage regimen for gatifloxacin in buffalo calves would be 5.3 mg/kg at 24 h intervals. Springer Science + Business Media, Inc., 2007 buffalo calves nationallicence dosage nationallicence gatifloxacin nationallicence pharmacokinetics nationallicence ATCC : American type culture collection nationallicence MIC : minimum inhibitory concentration nationallicence Raipuria M. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004, Ludhiana, India aut Dumka V. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004, Ludhiana, India aut Sandhu H. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004, Ludhiana, India aut Veterinary Research Communications Springer Netherlands 31/8(2007-11-01), 1013-1020 0165-7380 31:8<1013 2007 31 11259 https://doi.org/10.1007/s11259-007-3343-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11259-007-3343-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raipuria M. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004, Ludhiana, India aut NATIONALLICENCE 700 1- Dumka V. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004, Ludhiana, India aut NATIONALLICENCE 700 1- Sandhu H. Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004, Ludhiana, India aut NATIONALLICENCE 773 0- Veterinary Research Communications Springer Netherlands 31/8(2007-11-01), 1013-1020 0165-7380 31:8<1013 2007 31 11259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer