caa a22 4500 463238796 CHVBK 20180405153306.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s11259-006-3385-2 doi (NATIONALLICENCE)springer-10.1007/s11259-006-3385-2 Plasma Concentration of Insulin-like Growth Factor I (IGF-I) in Growing Ardenner Horses Suffering from Juvenile Digital Degenerative Osteoarthropathy [Elektronische Daten] [J.-Ph. Lejeune, T. Franck, M. Gangl, N. Schneider, C. Michaux, G. Deby-Dupont, D. Serteyn] Degenerative osteoarthropathy resulting in a reduced active lifespan was observed in Ardenner horses. In the context of joint biology, insulin-like growth factor I (IGF-I) is a potential candidate to affect the anabolism of cartilage matrix molecules. A group of 30 Ardenner horses reared under standardized conditions from weaning were evaluated periodically from 15 to 28 months of age to detect the early manifestations of the disease. At the end of this period, horses were classified in two pathological groups related to the degree of interphalangeal degenerative osteoarthropathy based on clinical and radiographic evaluations: healthy (46.7%) and pathological (53.3%) horses. Seven sequential blood samples were taken from each horse (during the evaluation period) to study the variation of IGF-I plasma concentration. We tested the variations of the IGF-I plasma concentration during growth, and the effect of sex and of pathological classes. Significant variations were observed during the research period, with a maximum value corresponding to spring and a minimum in autumn. A significant reduction of the IGF-I plasma concentration was also observed in the pathological horses (433.5 ± 19.5 ng/ml) compared to the healthy horses (493.9 ± 18.2 ng/ml). An alteration in the level of this growth factor could induce a disregulation of the mechanisms involved in the local control of joint and bone tissue development. Springer Science + Business Media, Inc., 2007 Ardenner nationallicence horse nationallicence IGF-I nationallicence joint disease nationallicence metabolism nationallicence ELISA : enzyme-linked immunosorbent assay nationallicence IGF-I : insulin-like growth factor I nationallicence IGFBP : insuline-like growth factor binding protein nationallicence IL-I : interleukin I nationallicence LSM : least-squares mean nationallicence MDG : mean daily gain nationallicence Lejeune J.-Ph Centre Européen du Cheval, Mont-le-Soie, Vielsalm aut Franck T. Center for Oxygen Research and Development, University of Liège, Liège, Belgium aut Gangl M. Department of Clinical Sciences, Large Animal Surgery, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium aut Schneider N. Centre Européen du Cheval, Mont-le-Soie, Vielsalm aut Michaux C. Department of Genetics, University of Liège, Liège, Belgium aut Deby-Dupont G. Center for Oxygen Research and Development, University of Liège, Liège, Belgium aut Serteyn D. Centre Européen du Cheval, Mont-le-Soie, Vielsalm aut Veterinary Research Communications Kluwer Academic Publishers 31/2(2007-02-01), 185-195 0165-7380 31:2<185 2007 31 11259 https://doi.org/10.1007/s11259-006-3385-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11259-006-3385-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lejeune J.-Ph Centre Européen du Cheval, Mont-le-Soie, Vielsalm aut NATIONALLICENCE 700 1- Franck T. Center for Oxygen Research and Development, University of Liège, Liège, Belgium aut NATIONALLICENCE 700 1- Gangl M. Department of Clinical Sciences, Large Animal Surgery, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium aut NATIONALLICENCE 700 1- Schneider N. Centre Européen du Cheval, Mont-le-Soie, Vielsalm aut NATIONALLICENCE 700 1- Michaux C. Department of Genetics, University of Liège, Liège, Belgium aut NATIONALLICENCE 700 1- Deby-Dupont G. Center for Oxygen Research and Development, University of Liège, Liège, Belgium aut NATIONALLICENCE 700 1- Serteyn D. Centre Européen du Cheval, Mont-le-Soie, Vielsalm aut NATIONALLICENCE 773 0- Veterinary Research Communications Kluwer Academic Publishers 31/2(2007-02-01), 185-195 0165-7380 31:2<185 2007 31 11259 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer