caa a22 4500 463245032 CHVBK 20180405153323.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s00422-007-0185-x doi (NATIONALLICENCE)springer-10.1007/s00422-007-0185-x An oscillator theory of motor unit recruitment [Elektronische Daten] [P. Prashanth, V. Chakravarthy] The phenomenon of systematic recruitment of motor units with increasing demand load is usually explained by the size principle. Though this principle successfully explains the gain-related aspects of muscle force generation, it does not address the need for desynchronization of motor unit activities in order to produce a smooth tension profile at the level of whole muscle, while individual muscle fibers are "twitching.” We propose an oscillator model of motor neurons in which a pool of motor neurons fires a bundle of muscle fibers. Although individual muscle fibers have a complicated tension profile, the tension produced by the entire bundle is regulated and follows a command signal accurately. This is shown to be possible because of uncorrelated activity produced by local inhibitory connections among motor neurons. Connections that produce synchronized oscillations result in uncontrolled contractions of the muscle. These results seem to suggest that while synchronized activity indicates pathology and disease, desynchronized activity is the precondition for normal muscle function. Physiological evidence for the proposed theory of motor unit synchronization is presented. Springer-Verlag, 2007 Motor unit nationallicence Recruitment nationallicence Synchronization nationallicence Muscle nationallicence Neural network nationallicence Prashanth P. Department of Electrical Engineering, Indian Institute of Technology, 600 036, Chennai, India aut Chakravarthy V. Department of Electrical Engineering, Indian Institute of Technology, 600 036, Chennai, India aut Biological Cybernetics Springer-Verlag 97/5-6(2007-12-01), 351-361 0340-1200 97:5-6<351 2007 97 422 https://doi.org/10.1007/s00422-007-0185-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0185-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prashanth P. Department of Electrical Engineering, Indian Institute of Technology, 600 036, Chennai, India aut NATIONALLICENCE 700 1- Chakravarthy V. Department of Electrical Engineering, Indian Institute of Technology, 600 036, Chennai, India aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 97/5-6(2007-12-01), 351-361 0340-1200 97:5-6<351 2007 97 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer