caa a22 4500 463245083 CHVBK 20180405153323.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s00422-007-0186-9 doi (NATIONALLICENCE)springer-10.1007/s00422-007-0186-9 Mean field model of acetylcholine mediated dynamics in the cerebral cortex [Elektronische Daten] [J. Clearwater, C. Rennie, P. Robinson] A recent continuum model of the large scale electrical activity of the cerebral cortex is generalized to include cholinergic modulation. In this model, dynamic modulation of synaptic strength acts over the time scales of nicotinic and muscarinic receptor action. The cortical model is analyzed to determine the effect of acetylcholine (ACh) on its steady states, linear stability, spectrum, and temporal responses to changes in subcortical input. ACh increases the firing rate in steady states of the system. Changing ACh concentration does not introduce oscillatory behavior into the system, but increases the overall spectral power. Model responses to pulses in subcortical input are affected by the tonic level of ACh concentration, with higher levels of ACh increasing the magnitude firing rate response of excitatory cortical neurons to pulses of subcortical input. Numerical simulations are used to explore the temporal dynamics of the model in response to changes in ACh concentration. Evidence is seen of a transition from a state in which intracortical inputs are emphasized to a state where thalamic afferents have enhanced influence. Perturbations in ACh concentration cause changes in the firing rate of cortical neurons, with rapid responses due to fast acting facilitatory effects of nicotinic receptors on subcortical afferents, and slower responses due to muscarinic suppression of intracortical connections. Together, these numerical simulations demonstrate that the actions of ACh could be a significant factor modulating early components of evoked response potentials. Springer-Verlag, 2007 Clearwater J. School of Physics, University of Sydney, 2006, Sydney, NSW, Australia aut Rennie C. School of Physics, University of Sydney, 2006, Sydney, NSW, Australia aut Robinson P. School of Physics, University of Sydney, 2006, Sydney, NSW, Australia aut Biological Cybernetics Springer-Verlag 97/5-6(2007-12-01), 449-460 0340-1200 97:5-6<449 2007 97 422 https://doi.org/10.1007/s00422-007-0186-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0186-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clearwater J. School of Physics, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Rennie C. School of Physics, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Robinson P. School of Physics, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 97/5-6(2007-12-01), 449-460 0340-1200 97:5-6<449 2007 97 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer