caa a22 4500 463245105 CHVBK 20180405153323.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00422-007-0171-3 doi (NATIONALLICENCE)springer-10.1007/s00422-007-0171-3 The role of cortical feedback in the generation of the temporal receptive field responses of lateral geniculate nucleus neurons: a computational modelling study [Elektronische Daten] [Nada Yousif, Mike Denham] The influence of cortical feedback on thalamic visual responses has been a source of much discussion in recent years. In this study we examine the possible role of cortical feedback in shaping the spatiotemporal receptive field (STRF) responses of thalamocortical (TC) cells in the lateral geniculate nucleus (LGN) of the thalamus. A population-based computational model of the thalamocortical network is used to generate a representation of the STRF response of LGN TC cells within the corticothalamic feedback circuit. The cortical feedback is shown to have little influence on the spatial response properties of the STRF organization. However, the model suggests that cortical feedback may play a key role in modifying the experimentally observed biphasic temporal response property of the STRF, that is, the reversal over time of the polarity of ON and OFF responses of the centre and surround of the receptive field, in particular accounting for the experimentally observed mismatch between retinal cells and TC cells in respect of the magnitude of the second (rebound) phase of the temporal response. The model results also show that this mismatch may result from an anti-phase corticothalamic feedback mechanism. Springer-Verlag, 2007 Corticothalamic feedback nationallicence Spatiotemporal receptive fields nationallicence Lateral geniculate nulceus nationallicence Computational modelling nationallicence Wilson and cowan equations nationallicence LGN : Lateral geniculate nucleus nationallicence PY : Cortical pyramidal cell nationallicence RE : Reticular cell nationallicence RE nucleus : Thalamic reticular nucleus nationallicence RF : Receptive field nationallicence RGC : Retinal ganglion cell nationallicence STRF : Spatiotemporal receptive field nationallicence TC : Thalamocortical cell nationallicence V1 : Primary visual cortex nationallicence Yousif Nada Centre for Computational and Theoretical Neuroscience, University of Plymouth, Drake Circus, PL4 8AA, Plymouth, UK aut Denham Mike Centre for Computational and Theoretical Neuroscience, University of Plymouth, Drake Circus, PL4 8AA, Plymouth, UK aut Biological Cybernetics Springer-Verlag 97/4(2007-10-01), 269-277 0340-1200 97:4<269 2007 97 422 https://doi.org/10.1007/s00422-007-0171-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0171-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yousif Nada Centre for Computational and Theoretical Neuroscience, University of Plymouth, Drake Circus, PL4 8AA, Plymouth, UK aut NATIONALLICENCE 700 1- Denham Mike Centre for Computational and Theoretical Neuroscience, University of Plymouth, Drake Circus, PL4 8AA, Plymouth, UK aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 97/4(2007-10-01), 269-277 0340-1200 97:4<269 2007 97 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer