caa a22 4500 463245237 CHVBK 20180405153324.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00422-006-0103-7 doi (NATIONALLICENCE)springer-10.1007/s00422-006-0103-7 Elliott Terry Department of Electronics and Computer Science, University of Southampton, SO17 1BJ, Highfield, Southampton, UK aut Intrinsic versus extrinsic influences in the development of neuronal maps [Elektronische Daten] [Terry Elliott] Accumulating evidence suggests that the plasticity of extrinsic thalamocortical inputs in cortical layer IV may be guided or instructed by earlier plasticity events in the intrinsic, horizontal connections within the extragranular cortical layers. We analyse a rate-based model of the plasticity of a set of extrinsic afferents in the presence of a pre-existing (and fixed) plexus of intrinsic, overall excitatory horizontal connections between a set of target neurons. We determine conditions under which afferent synaptic pattern formation respects this pre-existing lateral structure. We find three broad regimes under which extrinsic afferent plasticity may violate this structure: the initial pattern of extrinsic afferent innervation of the target cells is far from balanced; the gain of the extrinsic afferents greatly exceeds the overall scale of the strength of lateral excitation; the target cell horizontal coupling matrix is sparse. If none of these conditions is satisfied, then extrinsic afferent plasticity respects the pre-existing lateral connectivity, so that afferent synaptic pattern formation conforms to the pattern of lateral excitation. Springer-Verlag, 2006 Biological Cybernetics Springer-Verlag 96/1(2007-01-01), 129-143 0340-1200 96:1<129 2007 96 422 https://doi.org/10.1007/s00422-006-0103-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-006-0103-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Elliott Terry Department of Electronics and Computer Science, University of Southampton, SO17 1BJ, Highfield, Southampton, UK aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 96/1(2007-01-01), 129-143 0340-1200 96:1<129 2007 96 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer