caa a22 4500 46324530X CHVBK 20180405153324.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00422-007-0156-2 doi (NATIONALLICENCE)springer-10.1007/s00422-007-0156-2 A parameter-space search algorithm tested on a Hodgkin-Huxley model [Elektronische Daten] [Michael Reid, Edgar Brown, Stephen DeWeerth] We demonstrate a parameter-space search algorithm using a computational model of a single-compartment neuron with conductance-based Hodgkin-Huxley dynamics. To classify bursting (the desired behavior), we use a simple cost function whose inputs are derived from the frequency content of the neural output. Our method involves the repeated use of a stochastic gradient descent-type algorithm to locate parameter values that allow the neural model to produce bursting within a specified tolerance. We demonstrate good results, including those showing that the utility of our algorithm improves as the pre-defined allowable parameter ranges increase and that the initial approach to our method is computationally efficient. Springer-Verlag, 2007 Conductance-based Hodgkin-Huxley model nationallicence Gradient descent nationallicence Neural modeling nationallicence Oscillatory neural behavior nationallicence Parameter-space exploration nationallicence Reid Michael Laboratory for Neuroengineering, Georgia Institute of Technology, 313 Ferst Drive, 30332, Atlanta, GA, USA aut Brown Edgar Laboratory for Neuroengineering, Georgia Institute of Technology, 313 Ferst Drive, 30332, Atlanta, GA, USA aut DeWeerth Stephen Laboratory for Neuroengineering, Georgia Institute of Technology, 313 Ferst Drive, 30332, Atlanta, GA, USA aut Biological Cybernetics Springer-Verlag 96/6(2007-06-01), 625-634 0340-1200 96:6<625 2007 96 422 https://doi.org/10.1007/s00422-007-0156-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0156-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reid Michael Laboratory for Neuroengineering, Georgia Institute of Technology, 313 Ferst Drive, 30332, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Brown Edgar Laboratory for Neuroengineering, Georgia Institute of Technology, 313 Ferst Drive, 30332, Atlanta, GA, USA aut NATIONALLICENCE 700 1- DeWeerth Stephen Laboratory for Neuroengineering, Georgia Institute of Technology, 313 Ferst Drive, 30332, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 96/6(2007-06-01), 625-634 0340-1200 96:6<625 2007 96 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer