caa a22 4500 463245326 CHVBK 20180405153324.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00422-007-0151-7 doi (NATIONALLICENCE)springer-10.1007/s00422-007-0151-7 Effects of spinal recurrent inhibition on motoneuron short-term synchronization [Elektronische Daten] [Takanori Uchiyama, Uwe Windhorst] Spinal recurrent inhibition linking skeleto- motoneurons (α-MNs) via Renshaw cells (RCs) has been variously proposed to increase or decrease tendencies toward synchronous discharges between α-MNs. This controversy is not easy to settle experimentally in animal or human paradigms because RCs receive, in addition to excitatory input from α-MNs, many other modulating influences which may change their mode of operation. Computer simulations help to artificially isolate the recurrent inhibitory circuit and thus to study its effects on α-MN synchronization under conditions not achievable in natural experiments. We present here such a study which was designed to specifically test the following hypothesis. Since many α-MNs excite any particular Renshaw cell, which in turn inhibits many α-MNs, this convergence-divergence pattern establishes a random network whose random discharge patterns inject uncorrelated noise into α-MNs, and this noise counteracts any synchronization potentially arising from other sources, e.g., common inputs (Adam etal. in Biol Cybern 29:229-235, 1978). We investigated the short-term synchronization of α-MNs with two types of excitatory input signals to α-MNs (random and sinusoidally modulated random patterns). The main results showed that, while recurrent inhibitory inputs to different α-MNs were indeed different, recurrent inhibition (1) exerted rather small effects on the modulation of α-MN discharge, (2) tended to increase the short-term synchronization of α-MN discharge, and (3) did not generate secondary peaks in α-MN-α-MN cross-correlograms associated with α-MN rhythmicity. Springer-Verlag, 2007 Uchiyama Takanori Department of Applied Physics and Physico-Informatics, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, 223-8522, Kohoku-ku, Yokohama, Japan aut Windhorst Uwe Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Humboldtallee 23, 37073, Göttingen, Germany aut Biological Cybernetics Springer-Verlag 96/6(2007-06-01), 561-575 0340-1200 96:6<561 2007 96 422 https://doi.org/10.1007/s00422-007-0151-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0151-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uchiyama Takanori Department of Applied Physics and Physico-Informatics, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, 223-8522, Kohoku-ku, Yokohama, Japan aut NATIONALLICENCE 700 1- Windhorst Uwe Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Humboldtallee 23, 37073, Göttingen, Germany aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 96/6(2007-06-01), 561-575 0340-1200 96:6<561 2007 96 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer