caa a22 4500 463245385 CHVBK 20180405153324.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00422-006-0123-3 doi (NATIONALLICENCE)springer-10.1007/s00422-006-0123-3 Modeling the pre- and post-synaptic components involved in the synaptic modification between cones and horizontal cells in carp retina [Elektronische Daten] [Xu-Long Wang, Xin Jin, Pei-Ji Liang] In retinal synapses between cones and luminosity type horizontal cells (LHC), it was previously found in this laboratory that repetitive red flashes progressively strengthened the LHC's response to red flash, whereas weakened the LHC's response to green flash; repetitive green flash remarkably depressed the LHC's red response, but caused little changes in the cell's green response. However, the detailed mechanisms underlying these phenomena are not entirely clear. In the present study, based on an ion-channel model described mainly in the form of Hodgkin-Huxley equations, possible mechanisms of the short-term synaptic modification are investigated. The simulation results suggest that: (1) the auto-enhancement effect might be induced by the Ca2+-dependent process on the post-synaptic AMPA receptors, which could lead to changes of the ionic channel's properties; (2) the asymmetric response to red- and green-flashes and the mutual-chromatic suppression effects might be attributed to the regulatory effects on the presynaptic glutamate release. Springer-Verlag, 2006 Wang Xu-Long Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, 200240, Shanghai, China aut Jin Xin Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, 200240, Shanghai, China aut Liang Pei-Ji Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, 200240, Shanghai, China aut Biological Cybernetics Springer-Verlag 96/3(2007-03-01), 367-376 0340-1200 96:3<367 2007 96 422 https://doi.org/10.1007/s00422-006-0123-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-006-0123-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Xu-Long Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, 200240, Shanghai, China aut NATIONALLICENCE 700 1- Jin Xin Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, 200240, Shanghai, China aut NATIONALLICENCE 700 1- Liang Pei-Ji Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, 200240, Shanghai, China aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 96/3(2007-03-01), 367-376 0340-1200 96:3<367 2007 96 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer