caa a22 4500 463245431 CHVBK 20180405153324.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00422-007-0142-8 doi (NATIONALLICENCE)springer-10.1007/s00422-007-0142-8 The role of the striatum in adaptation learning: a computational model [Elektronische Daten] [Moritz Grosse-Wentrup, Jose Contreras-Vidal] To investigate the functional role of the striatum in visuo-motor adaptation, we extend the DIRECT-model for visuo-motor reaching movements formulated by Bullock etal.(J Cogn Neurosci 5:408-435,1993) through two parallel loops, each modeling a distinct contribution of the cortico-cerebellar-thalamo-cortical and the cortico-striato-thalamo-cortical networks to visuo-motor adaptation. Based on evidence of Robertson and Miall(Neuroreport 10(5): 1029-1034, 1999), we implement the function of the cortico-cerebellar-thalamo-cortical loop as a module that gradually adapts to small changes in sensorimotor relationships. The cortico-striato-thalamo-cortical loop on the other hand is hypothesized to act as an adaptive search element, guessing new sensorimotor-transformations and reinforcing successful guesses while punishing unsuccessful ones. In a first step, we show that the model reproduces trajectories and error curves of healthy subjects in a two dimensional center-out reaching task with rotated screen cursor visual feedback. In a second step, we disable learning processes in the cortico-striato- thalamo-cortical loop to simulate subjects with Parkinson's disease (PD), and show that this leads to error curves typical of subjects with PD. We conclude that the results support our hypothesis, i.e., that the role of the cortico-striato-thalamo-cortical loop in visuo-motor adaptation is that of an adaptive search element. Springer-Verlag, 2007 Grosse-Wentrup Moritz Institute of Automatic Control Engineering, Technische Universiät München, 80290, München, Germany aut Contreras-Vidal Jose Department of Kinesiology and Graduate Programs in Bioengineering and Neuroscience and Cognitive Science, University of Maryland, 20742, College Park, MD, USA aut Biological Cybernetics Springer-Verlag 96/4(2007-04-01), 377-388 0340-1200 96:4<377 2007 96 422 https://doi.org/10.1007/s00422-007-0142-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0142-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grosse-Wentrup Moritz Institute of Automatic Control Engineering, Technische Universiät München, 80290, München, Germany aut NATIONALLICENCE 700 1- Contreras-Vidal Jose Department of Kinesiology and Graduate Programs in Bioengineering and Neuroscience and Cognitive Science, University of Maryland, 20742, College Park, MD, USA aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 96/4(2007-04-01), 377-388 0340-1200 96:4<377 2007 96 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer