caa a22 4500 463245539 CHVBK 20180405153324.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00422-007-0146-4 doi (NATIONALLICENCE)springer-10.1007/s00422-007-0146-4 Developing velocity sensitivity in a model neuron by local synaptic plasticity [Elektronische Daten] [Minija Tamosiunaite, Bernd Porr, Florentin Wörgötter] Sensor neurons, like those in the visual cortex, display specific functional properties, e.g., tuning for the orientation, direction and velocity of a moving stimulus. It is still unclear how these properties arise from the processing of the inputs which converge at a given cell. Specifically, little is known how such properties can develop by ways of synaptic plasticity. In this study we investigate the hypothesis that velocity sensitivity can develop at a neuron from different types of synaptic plasticity at different dendritic sub-structures. Specifically we are implementing spike-timing dependent plasticity at one dendritic branch and conventional long-term potentiation at another branch, both driven by dendritic spikes triggered by moving inputs. In the first part of the study, we show how velocity sensitivity can arise from such a spatially localized difference in the plasticity. In the second part we show how this scenario is augmented by the interaction between dendritic spikes and back-propagating spikes also at different dendritic branches. Recent theoretical (Saudargiene et al. in Neural Comput 16:595-626, 2004) and experimental (Froemke et al. in Nature 434:221-225, 2005) results on spatially localized plasticity suggest that such processes may play a major role in determining how synapses will change depending on their site. The current study suggests that such mechanisms could be used to develop the functional specificities of a neuron. Springer-Verlag, 2007 Tamosiunaite Minija Department of Psychology, University of Stirling, FK9 4LA, Stirling, Scotland aut Porr Bernd Department of Electronics and Electrical Engineering, University of Glasgow, GT12 8LT, Glasgow, Scotland aut Wörgötter Florentin Department of Psychology, University of Stirling, FK9 4LA, Stirling, Scotland aut Biological Cybernetics Springer-Verlag 96/5(2007-05-01), 507-518 0340-1200 96:5<507 2007 96 422 https://doi.org/10.1007/s00422-007-0146-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00422-007-0146-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tamosiunaite Minija Department of Psychology, University of Stirling, FK9 4LA, Stirling, Scotland aut NATIONALLICENCE 700 1- Porr Bernd Department of Electronics and Electrical Engineering, University of Glasgow, GT12 8LT, Glasgow, Scotland aut NATIONALLICENCE 700 1- Wörgötter Florentin Department of Psychology, University of Stirling, FK9 4LA, Stirling, Scotland aut NATIONALLICENCE 773 0- Biological Cybernetics Springer-Verlag 96/5(2007-05-01), 507-518 0340-1200 96:5<507 2007 96 422 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer