caa a22 4500 463246160 CHVBK 20180405153326.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s10578-007-0055-8 doi (NATIONALLICENCE)springer-10.1007/s10578-007-0055-8 Divalproex Sodium for the Treatment of PTSD and Conduct Disordered Youth: A Pilot Randomized Controlled Clinical Trial [Elektronische Daten] [Hans Steiner, Kirti Saxena, Victor Carrion, Leena Khanzode, Melissa Silverman, Kiki Chang] We examined the efficacy of divalproex sodium (DVP) for the treatment of PTSD in conduct disorder, utilizing a previous study in which 71 youth were enrolled in a randomized controlled clinical trial. Twelve had PTSD. Subjects (all males, mean age 16,␣SD 1.0) were randomized into high and low dose conditions. Clinical Global Impression (CGI) ratings for core PTSD symptoms (Intrusion, avoidance and hyper arousal) were primary outcome measures, weekly slopes of impulsivity secondary ones. Intent-to-treat analyses showed significant positive associations between receiving high dose of DVP CGI's. Parallel analyses comparing outcome by drug level achieved strengthened the results. Springer Science+Business Media, LLC, 2007 PTSD nationallicence Conduct disorder nationallicence Divalproex sodium nationallicence Clinical trial nationallicence Steiner Hans Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut Saxena Kirti Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut Carrion Victor Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut Khanzode Leena Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut Silverman Melissa Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut Chang Kiki Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut Child Psychiatry and Human Development Springer Netherlands; http://www.springer-ny.com 38/3(2007-10-01), 183-193 0009-398X 38:3<183 2007 38 10578 https://doi.org/10.1007/s10578-007-0055-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10578-007-0055-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steiner Hans Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut NATIONALLICENCE 700 1- Saxena Kirti Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut NATIONALLICENCE 700 1- Carrion Victor Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut NATIONALLICENCE 700 1- Khanzode Leena Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut NATIONALLICENCE 700 1- Silverman Melissa Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut NATIONALLICENCE 700 1- Chang Kiki Division of Child Psychiatry and Child Development, Stanford University School of Medicine, 401 Quarry Road, 94305-5719, Stanford, CA, USA aut NATIONALLICENCE 773 0- Child Psychiatry and Human Development Springer Netherlands; http://www.springer-ny.com 38/3(2007-10-01), 183-193 0009-398X 38:3<183 2007 38 10578 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer