caa a22 4500 463248988 CHVBK 20180405153334.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s11130-006-0037-1 doi (NATIONALLICENCE)springer-10.1007/s11130-006-0037-1 Changes in Glycoprotein Components in Streptozotocin - Nicotinamide Induced Type 2 Diabetes: Influence of Tetrahydrocurcumin from Curcuma longa [Elektronische Daten] [LEELAVINOTHAN PARI, PIDARAN MURUGAN] Abstract.: Curcuma longa (Zingiberaceae) has been used traditionally as antidiabetic, and has been proven scientifically to possess high antioxidant activity and anticancer properties. The active components of Curcuma longa such as curcumin and tetrahydrocurcumin (THC), a major colourless metabolite of curcumin also possesses antidiabetic, antiinflammatory and antioxidant activity. The ethnopharmacological value of this plant, the effect of THC on glycoproteins was carried out in normal and streptozotocin-nicotiniamide induced type 2 hyperglycaemic rats for 45 days. Glucose, plasma insulin and glycoprotein components in plasma and tissues (hexose, hexosamine, fucose and sialic acid) were determined. Oral administration of THC to diabetic rats showed a decrease in the level of blood glucose and plasma glycoproteins. The levels of plasma insulin and tissue sialic acid were increased where as the levels of tissue hexose, hexosamine and fucose were near normal in diabetic rats treated with THC. The present study indicates that the THC possesses a significant beneficial effect on glycoprotein moiety in addition to its antidiabetic effect. The effect of THC is more prominent than curcumin. Springer Science+Business Media, Inc., 2007 Blood glucose nationallicence Curcumin nationallicence Diabetes mellitus nationallicence Glycoproteins components nationallicence Tetrahydrocurcumin nationallicence AGE : Advanced glycated endproducts nationallicence IL-6 : Interleukin-6 nationallicence STZ : Streptozotocin nationallicence THC : Tetrahydrocurcumin nationallicence TNF α : Tumor Necrosis Factor-α nationallicence PARI LEELAVINOTHAN Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India aut MURUGAN PIDARAN Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India aut Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 25-29 0921-9668 62:1<25 2007 62 11130 https://doi.org/10.1007/s11130-006-0037-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11130-006-0037-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- PARI LEELAVINOTHAN Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India aut NATIONALLICENCE 700 1- MURUGAN PIDARAN Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India aut NATIONALLICENCE 773 0- Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 25-29 0921-9668 62:1<25 2007 62 11130 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer