caa a22 4500 463249011 CHVBK 20180405153334.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s11130-006-0036-2 doi (NATIONALLICENCE)springer-10.1007/s11130-006-0036-2 Antihyperlipidemic Effect of Aronia melanocarpa Fruit Juice in Rats Fed a High-Cholesterol Diet [Elektronische Daten] [S. VALCHEVA-KUZMANOVA, K. KUZMANOV, V. MIHOVA, I. KRASNALIEV, P. BORISOVA, A. BELCHEVA] Aronia melanocrpa fruit juice (AMFJ) used in our experiment was very rich in phenolic substances (709.3mg gallic acid equivalents/100ml juice). Anthocyanins (106.8mg cyanidin-3-glucoside equivalents/100ml juice) were the main flavonoid group. The aim of this study was to assess the influence of AMFJ on plasma lipids and lipoprotein profile, and histopathology of liver and aorta in rats with dietary-induced hyperlipidemia. AMFJ was administered by gavage for 30 days at doses of 5, 10 and 20ml/kg body weight to rats fed a standard diet (SD) or a 4% cholesterol-containing diet (4% ChD). The 4% ChD caused a significant elevation of plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). AMFJ did not significantly influence plasma lipids in rats fed the SD and significantly hindered the elevation of plasma TC, LDL-C and TG in rats fed the 4% ChD. High-density lipoprotein cholesterol (HDL-C) levels were not significantly influenced either by the 4% ChD or by AMFJ. Neither the cholesterol feeding, nor AMFJ treatment induced any histopathological changes in rat liver and aorta. In conclusion, AMFJ showed an antihyperlipidemic effect in rats with hyperlipidemia and could be valuable in reducing this factor of cardiovascular risk. Springer Science+Business Media, Inc., 2006 Anthocyanins nationallicence Aronia melanocrpa fruit juice nationallicence Flavonoids nationallicence High-cholesterol diet nationallicence Plasma lipids nationallicence Total phenolics nationallicence AMFJ : Aronia melanocarpa fruit juice nationallicence ChD : cholesterol-containing diet nationallicence HDL-C : high-density lipoprotein cholesterol nationallicence LDL-C : low-density lipoprotein cholesterol nationallicence SD : standard diet nationallicence TC : total cholesterol nationallicence TG : triglycerides nationallicence VALCHEVA-KUZMANOVA S. Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55, Marin Drinov Str., 9002, Varna, Bulgaria aut KUZMANOV K. Vivarium, Medical University, Varna, Bulgaria aut MIHOVA V. Department of Clinical Laboratory, Medical University, Varna, Bulgaria aut KRASNALIEV I. Department of General and Clinical Pathology, Medical University, Varna, Bulgaria aut BORISOVA P. Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55, Marin Drinov Str., 9002, Varna, Bulgaria aut BELCHEVA A. Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55, Marin Drinov Str., 9002, Varna, Bulgaria aut Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 19-24 0921-9668 62:1<19 2007 62 11130 https://doi.org/10.1007/s11130-006-0036-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11130-006-0036-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- VALCHEVA-KUZMANOVA S. Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55, Marin Drinov Str., 9002, Varna, Bulgaria aut NATIONALLICENCE 700 1- KUZMANOV K. Vivarium, Medical University, Varna, Bulgaria aut NATIONALLICENCE 700 1- MIHOVA V. Department of Clinical Laboratory, Medical University, Varna, Bulgaria aut NATIONALLICENCE 700 1- KRASNALIEV I. Department of General and Clinical Pathology, Medical University, Varna, Bulgaria aut NATIONALLICENCE 700 1- BORISOVA P. Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55, Marin Drinov Str., 9002, Varna, Bulgaria aut NATIONALLICENCE 700 1- BELCHEVA A. Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55, Marin Drinov Str., 9002, Varna, Bulgaria aut NATIONALLICENCE 773 0- Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 19-24 0921-9668 62:1<19 2007 62 11130 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer