caa a22 4500 46324902X CHVBK 20180405153334.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s11130-006-0031-7 doi (NATIONALLICENCE)springer-10.1007/s11130-006-0031-7 Effect of Anthocyanin-Rich Extract from Black Rice ( Oryza sativa L. indica ) on Hyperlipidemia and Insulin Resistance in Fructose-Fed Rats [Elektronische Daten] [HONGHUI GUO, WENHUA LING, QING WANG, CHI LIU, YAN HU, MIN XIA, XIANG FENG, XIAODONG XIA] This study was designed to evaluate the effect of an anthocyanin-rich extract from black rice on hyperlipidemia and insulin resistance in fructose-fed rats. Rats fed fructose diet for 4 weeks exhibited significantly higher plasma insulin levels and lower insulin sensitivity than the control rats fed AIN-93G diet. Dietary supplementation with the anthocyanin-rich extract (5g/kg of high-fructose diet) prevented the development of fructose-induced insulin resistance. After fructose-induced insulin resistance had been established, 4-week treatment with the anthocyanin-rich extract (5g/kg of high-fructose diet) or pioglitazone (270mg/kg of high-fructose diet) ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructose-induced hyperinsulinemia as pioglitazone did. In addition, rats supplemented by the extract exhibited lower oxidative stress than the fructose-fed controls, as indicated by the lower concentrations of plasma thiobarbituric acid reactive substances and blood oxidized glutathione. Overall, these results suggest that the anthocyanin-rich extract from black rice improves certain metabolic abnormalities associated with diets high in fructose. Springer Science+Business Media, Inc., 2006 Anthocyanin nationallicence Black rice nationallicence Hyperlipidemia nationallicence Insulin resistance nationallicence Metabolic syndrome nationallicence Oxidative stress nationallicence AREBR : Anthocyanin-rich extract from black rice nationallicence AUC : Area under the curve nationallicence BW : Body weight nationallicence FFA : Free fatty acid nationallicence GSH : Reduced glutathione nationallicence GSSG : Oxidized glutathione nationallicence HDL-C : High-density lipoprotein cholesterol nationallicence HF : High fructose nationallicence HOMA-R : Relative-value of homeostasis model nationallicence LDL-C : Low-density lipoprotein cholesterol nationallicence TBARS : Thiobarbituric acid reactive substances nationallicence TC : Total cholesterol nationallicence TG : Triglyceride nationallicence GUO HONGHUI Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut LING WENHUA Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut WANG QING Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut LIU CHI Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut HU YAN Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut XIA MIN Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut FENG XIANG Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut XIA XIAODONG Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 1-6 0921-9668 62:1<1 2007 62 11130 https://doi.org/10.1007/s11130-006-0031-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11130-006-0031-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- GUO HONGHUI Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- LING WENHUA Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- WANG QING Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- LIU CHI Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- HU YAN Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- XIA MIN Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- FENG XIANG Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 700 1- XIA XIAODONG Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, 510080, Guangzhou, Guangdong Province, P. R. China aut NATIONALLICENCE 773 0- Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 1-6 0921-9668 62:1<1 2007 62 11130 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer