caa a22 4500 463249038 CHVBK 20180405153334.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s11130-006-0034-4 doi (NATIONALLICENCE)springer-10.1007/s11130-006-0034-4 Antihyperglycemic Effects of Platycodon grandiflorum (Jacq.) A. DC. Extract on Streptozotocin-induced Diabetic Mice [Elektronische Daten] [Jie Zheng, Jiguo He, Baoping Ji, Ye Li, Xiaofeng Zhang] Abstract.: The root of Platycodon grandiflorum (Jacq.) A. DC has been reported to have a wide range of health benefits in oriental food. This study examined the hypoglycemic effects of Platycodon grandiflorum (Jacq.) A. DC aqueous-ethanol extract (PGE) in streptozotocin (STZ) -induced diabetic ICR mice (STZ diabetic mice) for the first time. The effects of PGE on blood glucose, plasma insulin levels and body weight were investigated. A significant decrease in blood glucose levels was observed after single administration of PGE. Furthermore, Glibenclamide and PGE significantly suppressed the rise in blood glucose after 30 min in the acute glucose tolerance test. Treatment with glibenclamide and PGE resulted in a reduction in blood glucose levels from the 2nd week, and this reduction was maintained until the 4th week of treatment. The body weight changed slightly in glibenclamide and PGE treated mice in comparison with the STZ control group. Plasma insulin levels were increased with glibenclamide treatment in STZ diabetic mice, whereas such effect was not observed with PGE. These results indicated that PGE could induce hypoglycemic effects without stimulating insulin secretion. Springer Science+Business Media, Inc., 2007 p. grandiflorum nationallicence diabetic nationallicence streptozotocin nationallicence mice nationallicence b.w. : Body weight nationallicence PGE : Platycodon grandiflorum (Jacq.) A. DC aqueous-ethanol extract nationallicence STZ : Streptozotocin nationallicence STZ diabetic mice : Streptozotocin-induced diabetic ICR mice nationallicence Zheng Jie College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut He Jiguo College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut Ji Baoping College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut Li Ye College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut Zhang Xiaofeng College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 7-11 0921-9668 62:1<7 2007 62 11130 https://doi.org/10.1007/s11130-006-0034-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11130-006-0034-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zheng Jie College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut NATIONALLICENCE 700 1- He Jiguo College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut NATIONALLICENCE 700 1- Ji Baoping College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut NATIONALLICENCE 700 1- Li Ye College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut NATIONALLICENCE 700 1- Zhang Xiaofeng College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China aut NATIONALLICENCE 773 0- Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/1(2007-03-01), 7-11 0921-9668 62:1<7 2007 62 11130 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer