caa a22 4500 46324916X CHVBK 20180405153334.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s11130-007-0055-7 doi (NATIONALLICENCE)springer-10.1007/s11130-007-0055-7 Biochemical Characteristics of the Herb Mixture Prolipid as a Plant Food Supplement and Medicinal Remedy [Elektronische Daten] [Zenon Jastrzębski, Zev Tashma, Elena Katrich, Shela Gorinstein] Prolipid a known mixture of herbs is used as a plasma lipid lowering medicine. No side effects were registered. However, the bioactive substances of Prolipid were not investigated. Therefore in this investigation Prolipids bioactive compounds and antioxidant activity were studied. The contents of polyphenols and flavonoids were 19.87 ± 2.09 and 3.09 ± 0.31mg gallic acid equivalent GAE/g DW and 2.09 ± 0.24 and 0.57 ± 0.05mg catechin equivalent CE/g DW in water and methanol fractions, respectively. Anthocyanins (0.02 ± 0.001mg/g DW) and flavanols (7.58 ± 0.81μg CE/g DW) were found only in water fraction. The antioxidant activity of Prolipid, as determined by four different antioxidant assays [ferric-reducing/antioxidant power (FRAP); cupric reducing antioxidant capacity (CUPRAC); trolox equivalent antioxidant capacity (TEAC); 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH)], was higher in water than in methanol fraction. The correlation coefficients between polyphenols, flavonoids and antioxidant activities of Prolipid water extracts with TEAC were 0.97 and 0.90, respectively. It can be concluded that the content of polyphenol compounds in Prolipid is very high and they are the main contributors to Prolipids overall antioxidant activity. Prolipid is widely used in human treatment without known side effects on patients and is comparable to other medicinal plants, and as a strong antioxidant mixture could be used as a supplement to known atherosclerosis preventing diets. Springer Science+Business Media, LLC, 2007 Prolipid herb mixture nationallicence Plant food supplement nationallicence Antioxidants nationallicence Antioxidant activity nationallicence Radical scavenging assays nationallicence Jastrzębski Zenon Department of Pharmacology, National Medicines Institute, Chelmska str. 30/34, 00-725, Warsaw, Poland aut Tashma Zev Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel aut Katrich Elena Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel aut Gorinstein Shela Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel aut Plant Foods for Human Nutrition Springer US; http://www.springer-ny.com 62/4(2007-12-01), 145-150 0921-9668 62:4<145 2007 62 11130 https://doi.org/10.1007/s11130-007-0055-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11130-007-0055-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jastrzębski Zenon Department of Pharmacology, National Medicines Institute, Chelmska str. 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Tashma Zev Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 700 1- Katrich Elena Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 700 1- Gorinstein Shela Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 773 0- Plant Foods for Human Nutrition Springer US; http://www.springer-ny.com 62/4(2007-12-01), 145-150 0921-9668 62:4<145 2007 62 11130 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer